代谢综合征为严重危害人类健康的重大疾病，增加慢性肾病发生的风险，足细胞损伤是其早期发生预警信号。中医“化湿”从脾论治肾，芳香化湿中药苍术、厚朴及配伍临床疗效独特，但其作用机制和物质基础亟待阐明。课题组前期工作证实氧化应激、NLRP3炎症小体激活和炎症、胰岛素信号转导和脂代谢异常改变了代谢综合征肾小球足细胞免疫代谢，促进其损伤；部分中药具逆转作用。本项目拟在代谢综合征大鼠模型、代谢和免疫诱导因子刺激足细胞模型上，深入研究苍术、厚朴及配伍调控免疫代谢减轻足细胞损伤新途径；继之分析苍术、厚朴及配伍化学成分，探讨其抑制氧化应激和炎症反应，调节胰岛素信号及脂代谢等免疫代谢调控机制，确定其有效成分与组分。该工作将揭示苍术、厚朴调控免疫代谢减轻代谢综合征足细胞损伤“化湿”功效的作用机制和物质基础，为芳香化湿中药临床有效治疗代谢综合征提供科学依据，推动相关中药新药创制，对中药学学科发展将产生较深远的影响。

Metabolic syndrome is a major disease which seriously endangers human health, and increases the risk of developing chronic kidney disease. Podocyte injury is an early warning sign for the development of chronic kidney disease. Traditional Chinese medicine treats kidney disease from Spleen theory, the clinical applications of Rhizoma Atractylodis (Atractylodes Lancea), Cortex Magnoliae Officinalis (Magnolia officinalis) and their combinations, which are aromatic traditional Chinese medicines with removing dampness, have unique therapeutic effects. However, the mechanism of action and material basis should be elucidated. The previous results from our research group confirmed that oxidative stress, NLRP3 inflammasome activation and inflammation, insulin signal transduction impairment and lipid metabolic disorder changed immunometabolism in podocytes of metabolic syndrome. Some of traditional Chinese medicines reserved these disturbances. This project will investigate new ways to regulate immunometabolism and alleviate podocyte injury by Rhizoma Atractylodis, Cortex Magnoliae Officinalis and their combinations, in rat model of metabolic syndrome, as well as cell model of metabolic and immune inducing factors-exposed podocytes. Subsequently, this project will analyze the ingredients of Rhizoma Atractylodis, Cortex Magnoliae Officinalis and their combinations, and explore the mechanism of the regulation of immunometabolism involving in the inhibition of oxidative stress and inflammatory response, and the regulation of insulin signal transduction and lipid metabolism, and finally determine their active compounds. This project will reveal the action mechanism and material basis of resolving Dampness by which Rhizoma Atractylodis and Cortex Magnoliae Officinalis regulate immunometabolism to alleviate podocyte injury in metabolic syndrome. Moreover, this project will provide scientific basis for the effective treatment of metabolic syndrome with aromatic traditional Chinese medicines in clinic. These results are expected to promote the development of new drugs of Chinese medicine, and to have profound influences on the development of traditional Chinese medicine discipline.