为探索plasmonic协同增强传感新机制，解决传统plasmonic PEC纳米生物传感器所存在的活性材料种类单一，灵敏度低等问题，本申请拟通过“defects controllable engineering”技术合成新型钙钛矿基plasmonic纳米结构（TiO2@r-SrTiO3），并利用协同耦合增强策略引入Au纳米颗粒，通过界面结构设计构筑新型plasmonic PEC纳米生物传感器(TiO2@r-SrTiO3/AuNPs)，探索钙钛矿基plasmonic纳米结构(TiO2@r-SrTiO3)与Au纳米颗粒协同耦合增强传感新机制，揭示纳米结构与传感检测体系之间的构效关系及规律，从而有效提高传感器的检测灵敏度，实现重大疾病标志物的超灵敏、低成本检测。该研究可以为新型超灵敏纳米生物传感器的构建与临床应用提供重要的理论指导。

Recently, the construction of novel plasmonic PEC sensors faces great challenges due to the lacking of active materials and low sensitivity. In order to overcome these drawbacks and explore synergistically enhanced mechanism of plasmonic sensing, here we propose to prepare novel perovskite based plasmonic nanostructures（TiO2@r-SrTiO3）via defects controllable engineering strategy, and fabricate new type of plasmonic PEC nano-biosensors (TiO2@r-SrTiO3/AuNPs) through synergistic coupling method. By using this sensing system, the synergistic enhancement between plasmonic perovskite (TiO2@r-SrTiO3) and Au nanoparticles can be explored and ultrasensitive detection of major disease markers can be achieved. Meanwhile, the structure-activity relationship between nanostructure composition and sensors can be revealed, which will propose a new method to improve the sensitivity of the plasmonic PEC nano-biosensors and finally realize the ultrasensitive detection of major disease markers. This study will provide theoretical guidance for the construction and clinical application of the new type of nano-biosensors.