Cycloshizukaol A及Japonicones A-C是从金粟兰属植物中分离得到乌药烷倍半萜二聚体，复杂罕见的化学结构和特异的生物活性使其合成极具意义，但相关全合成工作尚未见报道。本项目针对此类天然产物核心十二元环骨架的构建方法进行研究，设计了串联双1，8-Michael加成/SN2取代反应，并将其应用于Cycloshizukaol A及Japonicones A-C的全合成中。拟利用串联Michael/Alkylation反应及特色的oxa-Pauson-Khand反应合成二聚单体片段，最后经过仿生[6+6]环加成反应完成目标分子的全合成。此研究将借助构筑十二元环的新方法和新策略，填补关于此类新型二聚体的合成空白，揭示自然界可能存在的仿生合成途径，具有重要的科学意义和学术价值。

The lindenane sesquiterpenoid dimers of Cycloshizukaol A and Japonicones A-C are isolated from the plants of Chloranthaceae. The complex chemical structure and specific biological activity make the total synthesis of such natural products extremely significant, but no total synthesis has been accomplished. This project focus on the construction of the most challenging core twelve-membered ring skeleton, we designed a double 1,8-Michael addition/SN2 substitution tandem reaction and this method was applied to the synthesis of Cycloshizukaol A and Japonicones A-C. Firstly, take advantage of tandem Michael/ Alkylation reaction and the characteristic oxa-Pauson-Khand reaction to synthetize dimer monomer fragment, and finally, the biomimetic [6 + 6] cycloaddition reaction completes the synthesis of the target molecules. The research will use new methods and new strategies to build a twelve-membered central ring system, filling the gaps in the synthesis of Cycloshizukaol A and Japononices A-C. Meanwhile, it reveals the relevant biomimetic synthesis process in nature, and has important scientific and academic significance.