含有手性环己烯酮骨架的化合物是合成多环萜烯、类固醇等大量天然产物和许多具有生理活性化合物的关键手性砌块。以手性化合物为原料来构建手性环己烯酮骨架受限于手性化合物的结构和来源。不对称Robinson型环化反应可以高效构建手性环己烯酮骨架。目前该类Robinson型环化反应局限于1，3-二羰基化合物与烯醛或烯酮、醛与烯酮之间的反应。 酮类化合物具有来源广、价格低、性质稳定、易存放等特点，申请人拟对酮与烯醛和烯酮的不对称Robinson型环化反应构建手性环己烯酮骨架进行研究。采用单催化剂双催化模式或双催化剂双催化模式：手性胺与酮形成烯胺活化酮、手性胺与烯醛或烯酮形成亚胺盐活化烯醛或烯酮（或手性硫脲与烯醛或烯酮形成氢键络合物活化烯醛或烯酮），实现酮与烯醛或烯酮之间的不对称Robinson型环化反应、高效构建手性环己烯酮骨架。该合成路线短，原子经济性高，污染小，符合"绿色低碳，节能减排"环保要求。

Compounds containing chiral cyclohexenone skeleton are versatile building blocks for the synthesis of a large number of natural products and bioactive compounds. Construction of chiral cyclohexenone skeleton from chiral substrates is limited by the structures and sources of chiral substrates. Asymmetric Robinson annulations offer a high efficient methodology to synthesize the chiral cyclohexenone skeleton. However, this type of annulations is limited in the reactions between 1,3-dicarbonyl compounds and enals / enones or the reactions between aldehydes and enals / enones. Due to the abundant sources, low cost, and stable properties of ketones, construction of chiral cyclohexenone skeleton via asymmetric Robinson annulation between ketones and enals / enones is of most importance. Authors have a high motivation to develop a "mono catalyst-bifunction or two catalysts-dual function" catalytic system that can activate both reactants and effect the Robinson annulation with excellent efficiency and stereoselectivity. In this catalytic system, the chiral amine is employed to activate ketone via enamine and the chiral amine or chiral thiourea is supposed to activate enal / enone via imine salt or the hydrogen bond, respectively. As a result, both ketone and enal /enone are activated, which leads to a high efficient and enantioselective Robinson annulation. Importantly, this step economy strategy has the advantages of brief procedure, high atom economy, enviroment friendly and easy to operate.