咪唑阳离子是近年发现的可以与阴离子形成(C-H)+ …X 离子型氢键的新型受体，在分析化学的研究中具有潜在的应用价值，然而单个咪唑阳离子由于其低的电荷密度很难满足电分析化学的研究需求。本项目拟利用咪唑阳离子优良的分子识别功能，通过对聚咪唑阳离子进行合理设计和功能化，系统开展基于聚咪唑阳离子的生物活性分子电化学分析新原理和新方法研究，并探索方法在实际样品（如微透析液和血清等）中的实用性。研究内容包括：1)聚咪唑阳离子的设计、合成与表征；2)聚咪唑阳离子与客体（待测物）之间的相互作用研究；3)生理活性物质（如ATP、过氧化氢、焦磷酸根、DNA等）电化学分析新原理和新方法的建立；4)方法在实际样品（如微透析液和血清等）分析中的实用性研究。本项目的实施不仅可以大大促进电化学分析新原理和新方法的发展，而且将会进一步促进电分析化学和超分子化学的交叉和融合。

Among the various types of anion receptors, imidazolium-based receptors have received a great deal of attention because they can form strong (C-H)+…X- ionic hydrogen bonds with various anions. Moreover, the physical and chemical properties of the imidazolium-based synthetic receptors could be easily tuned by varying the substituent groups and/or degree of polymerization. However, it is difficult by using single imidazolium to develop electrochemical methods due to its lower charge density. In this project, we wish to develop new electroanalytical principles and methods by using the strong recognition of imidazolium with anions. To accomplish this goal, the polyimidazolium was firstly designed and synthesized by adjusting the functional group on the imidazolium. This project includes the design and synthesis of polyimidazilium, investigations on the interaction between the polyimidazolium and stimulus; developing new analytical methods based on the polyimidazolium and the investigations on the validity of the developed methods. We believe this project will essentially promote the crosstalk between the supramolecular and electroanalysis.