糖异生是维持体内血糖稳态的重要代谢过程，糖异生调控的失衡是2型糖尿病的典型特征。激素是调控糖异生的最重要方式之一，而寻找新的调控糖异生的激素是代谢研究的一个重要前沿方向。我们通过全基因组siRNA筛选确定了一个全新的调控糖异生的基因，其编码的蛋白质有分泌的特性，将其命名为PANDA。PANDA促进糖异生，提高血糖水平。在本课题的研究中，我们将围绕PANDA参与糖异生调控这一重要问题，针对其分泌型和跨膜型两种调控糖异生的可能性，系统性分析PANDA调控糖异生的分子调控网络以及在相关代谢性疾病中的病理机制。

Gluconeogenesis maintains glucose homeostasis, while enhanced gluconeogenesis is one of the hallmarks of type 2 diabetes. Since hormonal regulation of glucose metabolism is one of the most critical ways to orchestrate glucose homeostasis, it is very important to identify such novel hormones. Here we have identified a novel regulatory gene of gluconeogenesis by genome-wide siRNA screening and named it PANDA, which encodes a secreted protein and promotes glucose production. In this study, we will systematically investigate the functional network of glucose homeostasis modulated by PANDA to uncover its role in gluconeogenesis and in diabetes.