SUN调控肝脏糖异生的分子机制

糖异生是维持体内血糖稳态的重要代谢过程，受到激素与营养信号的调控。糖异生调控的失衡是糖尿病的典型特征。寻找新的调控糖异生的内分泌因子是代谢研究的一个重要前沿方向。我们通过全基因组siRNA筛选影响糖异生的基因以及小鼠血清蛋白质组的分析，确定了一个全新的调控糖异生的基因，将其命名为SUN（SUN Wukong，孙悟空）。在本课题的研究中，我们将围绕SUN参与糖异生调控这一重要问题，针对其内分泌和转录调控糖异生的两个不同特征与机制，利用构建的Sun基因敲除小鼠，综合采用生理学、遗传学、分子细胞生物学、蛋白质组学、基因组学和生物信息学等方法，系统性分析SUN调控糖异生的分子调控网络以及在相关代谢性疾病中的病理机制。

Gluconeogenesis is dynamically regulated in response to hormonal and nutritional signals to maintain glucose homeostasis, while the impaired gluconeogenesis is one of the hallmarks of diabetes. Searching novel endocrine factors or hormones is a frontier field of metabolism research. Here we have identified a novel gene to modulate gluconeogenesis by genome-wide siRNA screening and mouse serum proteomic analysis and named it SUN (SUN Wukong). Therefore, we will focus on its endocrine and transcriptional effect of SUN on glucose homeostasis and systematically investigate its regulatory network to uncover the regulatory mechanisms of SUN in gluconeogenesis and in diabetes.