神经母细胞瘤（NB）是儿童最常见的颅外实体肿瘤，异质性是NB的主要特征，预后转归或自然退化、或迅猛进展，因此治疗前需准确的危险度分层。目前危险度分层中最重要的一个指标是基因检测结果，而获得基因检测所需的标本有一定的创伤性，PET/CT和123I-MIBG SPECT/CT显像是NB诊疗中两种无创的、核医学显像方法。我们初步的影像基因组学结果显示NB的PET/CT影像特征与预后基因-MYCN有很好的相关性。但NB患者主病灶、棕色脂肪的18F-FDG、123I-MIBG影像特征与NB的预后基因间的关系尚不清楚。本课题通过对NB的PET/CT和123I-MIBG SPECT/CT进行影像基因组学研究，探索新的影像基因组学特征，并基于上述特征建立新的NB PET/CT和123I-MIBG SPECT/CT淋巴结转移、疗效和预后的预测模型，同时研究棕色脂肪影响神经母细胞瘤细胞发生、发展的相关机制。

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Heterogeneity is the main feature of NB. The prognosis of NB is natural degeneration, or rapid progression. Therefore, accurate risk stratification before therapy is required. The most important indicator in the current risk stratification is the results of genetic testing. The acquisition process of specimens for genetic testing is invasive. 18F-FDG PET/CT and 123I-MIBG SPECT/CT scans are two non-invasive, nuclear medicine methods in NB diagnosis. Our preliminary radiogenomics results showed that the 18F-FDG PET/CT features of the tumor were well correlated with the prognosis gene--MYCN. However, the relationship between 18F-FDG, 123I-MIBG imaging features of the main lesions of NB, brown adipose tissue and the prognosis genes of NB is still unclear. This aim of the present project is to explore new NB radiogenomics features based on PET/CT and 123I-MIBG SPECT/CT radiogenomics study, to establish lymph node metastasis, therapy response, prognostic prediction model based on the 18F-FDG PET/CT and 123I-MIBG SPECT/CT radiomics characteristics. At the same time, we wanted to investigate the molecular mechanism of brown adipose tissue affecting the development and progression of neuroblastoma cells.