去甲肾上腺素（noradrenaline, NA）参与调节与奖赏相关的认知过程，尤其在涉及奖赏不确定性的风险决策中具有关键作用。对奖赏不确定性的评估是风险认知的核心，因此NA对风险认知的作用机制十分重要。本项目将围绕NA系统对大鼠风险决策的影响及其神经机制展开研究：1）从行为学水平，在经典的概率折扣任务基础上提出“双赢”框架下的风险决策任务，以特异性考察风险认知对决策偏好的影响及NA系统分别对高低风险偏好大鼠决策的影响；2）在此基础上考察NA α2受体拮抗剂在前额叶皮层-基底外侧杏仁核环路的上行、下行通路中对风险决策的作用机制；3）从分子生物学水平，通过c-fos免疫组化及微透析-高效液相分析对该环路内神经活动及NA做定性和定量分析。本项目旨在通过设置双赢框架，揭示NA在个体决策偏好和策略转换中的作用，探讨NA对高低风险偏好大鼠风险决策的影响及其机制，为决策失调提供干预策略。

Noradrenaline (NA) is involved in the regulation of cognitive-related cognitive processes, especially in risk decisions related to reward uncertainty, and assessment of reward uncertainty is a core part of risk perception. The impact of NA on risk perception is important. The present research will focus on the impact of NA system on rat risk decision-making and develop the neural mechanism. (1) Based on the behavioral level, the risk decision task under the framework of “win-win” was designed based on the classic probability discounting task. The risk decision-making preference of the rats and the influence of the NA system on the decision-making of high-low risk preference rats were investigated. (2) The effect of NA alpha 2 receptor on risk decision-making in the ascending/descending pathway of the prefrontal cortex-basolateral amygdala loop was further investigated. (3) From the level of molecular biology, the NA in the high and low risk preference group was qualitatively and quantitatively analyzed by c-fos immunohistochemistry and Microdialysis-High performance liquid chromatography biochemical analysis. We hope to explore the impact of NA on individual decision-making tendencies and strategy transformation in risk decision-making through the establishment of a win-win framework, which will help us understand the mechanism of risk decision-making and provide intervention strategy for decision-making anomalies.