目前远处转移是鼻咽癌治疗失败的最主要原因。从分子水平深入研究导致鼻咽癌转移的关键分子，是实现鼻咽癌个体化治疗、降低转移率的重要途径。我们前期实验初步发现：①FNDC3B基因在鼻咽癌中倾向使用变短的3’UTR转录本，3’UTR长度不同的转录本对鼻咽癌细胞迁移和侵袭的影响存在差异；② FNDC3B基因在鼻咽癌细胞株中mRNA和蛋白表达水平升高。瞬转siFNDC3B后可抑制鼻咽癌细胞的迁移和侵袭能力。在此研究基础上，本项目将继续开展：①采用定量PCR的方法检测300例鼻咽癌组织，确认FNDC3B基因对鼻咽癌预后和远处转移的预测价值；②通过细胞功能实验和动物实验进一步明确FNDC3B基因在鼻咽癌远处转移中的功能和机制；③阐明FNDC3B基因3’UTR长度多态性在鼻咽癌远处转移中的功能和机制。通过本项目的实施，可为鼻咽癌治疗提供潜在的新靶点，为实现个体化治疗奠定基础，最终降低远处转移率。

Currently, distant metastasis is the main reason for the treatment failure of naopharyngeal carcinoma. Conducting in-depth research on the molecular mechanism of the key molecular markers in the metastatic process, is an important way to achieve individualized treatment of nasopharyngeal carcinoma and reduce its distant metastasis rate.In primary study,we found that ①FNDC3B genes tend to use shorter 3'UTR transcript in NPC and different 3'UTR length transcripts of FNDC3B have different effects on nasopharyngeal carcinoma cell migration and invasion; ② The mRNA and protein level of FNDC3B increased in nasopharyngeal carcinoma cell lines. After transient transfection of siFNDC3B, the migration and invasion ability of nasopharyngeal carcinoma cells are significantly suppressed. On this basis, the subject intends to continue to carry out: ① Examine the expression level of FNDC3B in 300 NPC patients with matched clinical data, to eveluate predictive value of FNDC3B gene in NPC prognosis and metastasis; ② Further clear the function and molecular mechanism of FNDC3B in the process of distant metastasis of nasopharyngeal carcinoma by cell function and animal experiments; ③ clarify the functions and mechanisms of the 3'UTR length polymorphism of FNDC3B in the metastasis process of NPC. Through this research implementation, it could provide potential new targets for individual therapy in patients with nasopharyngeal carcinoma and eventually decrease the distant-metastasis rate of patients with nasopharyngeal carcinoma.