普通合成方法所得4,4′-双酚F含量偏低，难以满足合成大型风电叶片双酚F环氧树脂基材的高性能与加工成型要求，急需研发具有自主知识产权的4,4′-双酚F的高选择合成方法。本项目研究以苯酚和甲醛为原料，基于小分子空间位阻协同离子液体催化高选择性合成4,4′-双酚F的绿色化学合成新方法。研究引入小分子脲醛树脂引导基与甲醛结合，增大甲醛与苯酚邻位空间位阻而使其主要与空间位阻较小的苯酚对位结合，反应后再脱去引导基的方法。研究兼具溶剂与催化双功能的咪唑类离子液体酸性对双酚F合成反应中亲电基团的稳定性影响，确定有利于亲电基团与苯酚对位结合的选择性反应条件。研究改变离子液体酸性对调控小分子脲醛树脂与甲醛结合力，促进小分子脲醛树脂空间位阻作用，高选择性合成4,4′-双酚F的协同作用。本研究对精细有机合成中4,4′-双酚类化合物的高选择性合成方法等共性问题亦具有一定的普遍意义。

Lower 4,4 '-isomer bisphenol F content synthesized by ordinary chemical synthesis methods is unable to meet the high performance and processing molding requirements of the synthesied bisphenol F epoxy resin as a body material for large-scale wind turbine blades，so it is badly in need to develop a highly selective synthesis method of 4,4'-bisphenol F with independent intellectual property.This project researces on a green chemical synthesis method of highly selective catalytic synthesis of 4,4'-bisphenol F from phenol and formaldehyde, based on the acidic ionic liquid catalysis cooperated with the steric hindrance of small molecules. An urea-formaldehyde resin of small molecules is used as an introductory group combined with formaldehyde to increase the ortho position steric structure hindrance of phenol and make formaldehyde combine with phenol at the para position of smaller steric structure hindrance, when formaldehyde combines with phenol. After the reaction is completed, the introductory group is drew off. The acidic effect of imidazole ionic liquid which have both functions of catalysis and solvent on the stability of electrophilic groups in the synthesis process of bisphenol F were researched to determine the favorable selective conditions of electrophilic groups combining with phenol at the para position.The synergy action of highly selective synthesis of 4,4′-bisphenol F was researched, which is a promoted effect of the steric structure hindrance of small molecule urea-formaldehyde resin by changing ionic liquid acidity so as to change the bonding force between small molecule urea-formaldehyde resin and formaldehyde. The method proposed in this project has important significance for highly selective synthesis of 4,4 '-bisphenol compounds in fine organic synthesis.