基于文献调研及研究积累，总结并提出“结构域路易斯(L)酸催化”概念。以二氯二茂钛/锆及其衍生物为原料，以芳香环上具有邻位羧基和羟基或氨基为基本结构单元的羧酸衍生物为配体，构建以羧基为配位基、以环系结构为桥梁、以茂金属为L酸骨架中心、以羟基为布朗斯特(B)酸或氨基为B碱的二茂金属结构域L酸配合物。基于结构域概念，从L酸酸性中心出发，通过金属中心的变换、茂环取代基电子效应及环结构的演化、配体取代基电子效应、环系结构的芳香性、空间效应、杂原子效应及位置的调变、B酸碱调配，施行四维度结构调控，实现分子内结构与性质关联；通过配合物催化活性检测，揭示茂金属L酸结构域效应。再以配合物为催化剂，以曼尼希反应、比吉内利反应及氮杂D-A反应为模型，以羰基化合物为活化对象，考察醛与胺及其衍生物进行缩合的C-C/N成键反应，关联结构与催化性能，建立结构域L酸分子内酸碱催化新体系，丰富L酸催化化学，推进实际应用。

Based on the literature research and our previous work, a concept of “Structural Domain Lewis Acid Catalysis”is proposed. The metallocene Lewis acid complexes are designed with titanoceneorzirconocene dichloride as stable Lewis acid precursors, which coordinate with functionalized carboxylic acids featured the aromatic hydroxyl group as Brønsted acid site or amino groups as Brønsted base site, and intramolecular bridges of aromatic rings, respectively. According to the concept of the structural domain, four dimensional structural controls over metal centers, electronic and steric property of Cp ligands, aromatic and heteroaromatic cyclic structures, and acid or base ligands are developed to tune the catalytic activity of metallocene Lewis acids in order to establish the intriguing relationship between molecular structures and their catalytic properties. To clearly demonstrate the catalytic significance of the structural domain, designed Lewis acid complexes catalyzed C-C and C-N bond formation reactions will be investigated. Mannich reaction, Biginelli reaction and aza-Diels-Alder reaction are chosen to evaluate the activity of Lewis acid catalysts which might synergistically activate organic carbonyl compounds and further condensation reactions of aldehyde compounds and amino derivatives. The novel acid-base cooperative catalysis system of the structural domain Lewis acid are the key to understand the relationship between complex structures and their properties, which will broaden the research field of the Lewis acid chemistry and their application in transition metal catalysis.