以Cp2TiCl2为原料，以苯环上具有相邻羟基和羧基为基本结构单元的磺酸衍生物为配体，构建以相邻羟基和羧基的苯环结构为桥梁、以二茂钛为Lewis酸骨架中心、以磺酸基为Br?nsted酸基本单元的二茂钛Lewis-Br?nsted酸配合物。基于Lewis酸性中心原子的电子密度决定其强度的策略，保持二茂钛结构单元不变，调节强吸电子作用的磺酸基个数与位置，实现分子内Br?nsted酸对Lewis酸中心酸性强度的调控；通过相应配合物催化活性检测，揭示Br?nsted酸与Lewis酸的协同作用机制。再以配合物为催化剂，以酯化/酰胺化反应为模型，以酸酐或酯为活化对象，考察醇、酚和胺的酯化、酯交换及酰胺化反应，关联结构与催化性能间的关系，揭示催化剂对催化三类反应的差异性，建立分子内Lewis-Br?nsted酸的多酸催化新体系，丰富Lewis及Br?nsted酸催化化学，推进酯化/酰胺化反应实际应用。

A serious new Lewis-Br?nsted acid titanocene complexes will be designed using Cp2TiCl2 as the start materials and sulfonic derivatives with O-hydroxycarboxylic groups of benzene as ligands. In the complex structures, O-hydroxyl and carboxyl groups will be acted as a bridge to coordinate with Ti atom, and titanocene will be as a frame and sulfonic group as a uint of Br?nsted acid in them. Based on the thought that the acidity of Lewis acid depends on the density of the central metallic atom, the acidity of titanocene Lewis acid will be controlled by the Br?nsted acid in molecule itself when tuned the quantity and the position of sulfonic group of the benzene ring as the constant of titanocene species. To further evidence this opinion, the intramolecular cooperative effect between Lewis acid and Br?nsted acid will be revealed through the exploration of the catalytic activation of complexes in this case. Then, a series of reactions will be investigated, such as esterification, interesterification and amidation of alcohols, phenols and amine dierivatives, respectively, when utilized the synthesized titanocene complexes as catalysts to active acid anhydrides or esters. To be the great expectation, a new multi-acid catalysis system of the intramolecular Lewis-Br?nsted acid will be proposed to understand the relationship between these titanocene complex structures and their properties, to reveal the difference of the catalytical behavior in three different reactions, to broaden the research field of the Lewis-Br?nsted acid chemistry and to push the appliation of the interesterification or amidation in this proposal.