组织形态发生中大范围的细胞变化如迁移、形变，必须是协同的，以保证在特定的时空下，组织或器官可正常形成。细胞这种协同行为是如何被调控的？有没有一个调控中心存在来协调整个组织的形态发生目前仍不清楚。我们最近的研究发现，果蝇卵巢中极细胞（PC）可调控其周围滤泡细胞（FC）层的形态发生，且此调控很可能依赖于PC产生的机械力。我们根据前期结果提出假设：果蝇卵子发生中，PC可作为调控中心，通过内部Myo-II的震荡产生机械力，这种机械力不仅改变其自身形态，同时也可传递至FC，并通过PCP信号通路协调Ecadherin，actomyosin的极性分布，从而协调FC有序地进行形态发生。为了验证该假说，我们将利用细胞生物学，发育生物学，遗传学，并借助光遗传学，活体影像等技术阐明PC对FC形态发生的作用及调控机制。本研究的顺利开展，将有助于我们更好地理解上皮层形态发生过程中机械力传导的生物意义。

Tissue morphogenesis involves collective cell behavior that is controlled and coordinated at the scale of the tissue to ensure the successful formation of tissues or organs at particular space-time. But how is this coordinated cell responses regulated? Is it possible that an organizing center exists to coordinate the whole tissue morphogenesis？Our recent findings showed that polar cells (PC) in the Drosophila ovary could regulate the morphogenesis of epithelial follicle cells (FC), and it is very likely through the PC-generated mechanical force. Therefore, according to our preliminary results we proposed: In the Drosophila oogenesis, PC function as an organizing center. Through the mechanical force generated by intracellular Myo-II oscillation, PC undergo shape change and transmit force to FC. Such transduction of mechanical force patterns the polarized distribution of Ecadherin and actomyosin through PCP signaling pathway and finally synchronizes FC morphogenesis. To validate this hypothesis, we will combine cellular, developmental and genetic approaches as well as optogenetic technique and live imaging to clarify the functions and regulated mechanisms of PC in the morphogenesis of FC. This study will improve our understanding of the role of mechanical force transduction during epithelial morphogenesis during development.