针对国内外太赫兹（THz）科学技术发展的现状与趋势，以及太赫兹技术在生命科学领域应用时灵敏度低、适用样品类型受限及数据可靠性差等突出问题，本项目提出利用新型石墨烯-超材料微结构器件与自主研发的微流室，研究太赫兹波免标记生物分子检测的机理和方法的课题。综合利用物理学、分子动力学、分子生物学和化学计量学知识，研究石墨烯-超材料微结构器件增强太赫兹辐射的机理，分析在不同太赫兹波入射条件下微结构器件结构和材料对太赫兹辐射输出效率的影响。研究微流室内流速和结构参数对生物分子的太赫兹波谱的影响，制备理想的微流室，在此基础上，研究生物分子的太赫兹波谱实时获取与处理方法。同时，研究太赫兹波谱解析生物分子及其相互作用行为的方法。最后获得优化的检测系统并扩大应用，实现对其它不同研究对象的检测。本项目研究有助于推进太赫兹科学技术的进一步发展，为其在生命科学及生物医学等领域的广泛应用奠定基础。

According to the current development and trend of terahertz (THz) technology, as well as the weakness of low sensitivity, limited object types and poor data reliability in life science field application,we propose a topic to realize a label-free detection of biological molecular using terahertz technology, with an efficient combination of graphene-metamaterial microstructure device and designed microfluidic cell. Based on physics, molecular dynamics, molecular biology and chemometrics knowledge, the mechanism of terahertz radiation enhancement due to graphene-metamaterial microstructure device will be extensively intestigated. The influence of the parameters of device structure and device material at different incidence beams on terahertz radiation efficience will be analyzed. The influence of flow velocities and structure parameters of microfluidic cell on biological molecular terahertz spectrum will be studied. And the reasonable cell will be developed. Based on above research, the methods to collect in real time and process biological molecular spectra will also be researched. The method that terahertz spectroscopy is used to analyze biological molecular and their reaction behavior will be developed. At last, the detection system will be optimized and other biological moleculars will be detected for further application. The research will improve the further development of terahertz technology and provide a solid foundation for the large-scale application in the fileds of life science and biomedicine.