Myrrhine是瓢虫“反射出血”现象分泌的一种Azaphenalene类生物碱，Alkaloid (-)-205B是草莓箭毒蛙的皮肤中分离的一种8b-azaacenaphthylene类生物碱，二者由于新颖的化学结构和潜在的药用价值而引起有机合成化学家的极大兴趣。目前已报道的全合成都是将两个分子独立进行合成，未考虑二者的相关性。本项目基于两个天然产物分子的结构特征，设计了一条可用于Myrrhine和Alkaloid (-)-205B的简洁、直接的合成路线；同时本项目也设计合成其类似物，以用于研究取代基对生物活性的影响。

Myrrhine is alkaloid with an azaphenalene ring system which secreted by Coccinellidae in the process known as “reflex bleeding”, and Alkaloid (-)-205B is alkaloid with a 8b-azaacenaphthylene ring system isolated from Dendrobates pumilio. They attracted great interesting of organic chemical communities for their novel structure and potential medical value. Till now, total syntheses of these two natural alkaloids were accomplished almost independently without considering their correlation. In this object, we designed a concise and straightforward synthetic route for Myrrhine and Alkaloid (-)-205B based on their structural feature. The project also includes the analogs synthesis to apply to study the effect of substituent on the biological activity.