生物体内的无机矿物组织通过复杂的生物矿化而形成，无机矿物初期及发育过程中矿物结晶形态、结晶程度、晶型与取向等的选择与演变直接与硬组织的形成密切相关。在前期体外模拟系统研究的基础上，项目进一步优化系统参数，强化系统功能，实现对各参数的精确、协同控制，建立精确模拟人体生理环境的受限反应空间；系统研究模拟离子浓度、体液流速、温度、电场强度、磁场强度等参数在复杂矿化过程中对矿物调控的基本规律，并建立相应的生物活性体外评价标准，为类骨矿物的精确仿生及其生物调控机制理论提供基 础。 该项目的实施对于骨修复材料的生物活性评价及智能型骨修复材料的制备具有重要的意义，能够为新一代具有良好骨结合性能的植入材料的发展提供理论基础和拓展途径。

Inorganic minerals of human beings are formed via complex biomineralization, the formation of hard tissue organs are closely and directly related with the evolution of mineral crystal morphology, crystallinity and crystal orientation in the early formation of inorganic minerals. In this project, we will focus on the studies of optimizing parameter of vitro simulation system, strengthening system functions, precise and cooperative control of various parameters, and the formation of restricted reaction space which can simulate the physiological environment accurately. Basic law of mineral regulation of parameters, such as electric field, magnetic field, simulated body fluid parameters of the flow rate, electric field strength, magnetic fieldstrength, ion concentration will be studied systemically in the formation of bio minerals.Biological activity evaluation criteria will be established. The implementation of this project is useful for providing orentical basis for biological activity evaluation and desiging of bone repair materials.