核小体定位和重塑与DNA序列的组成偏好紧密相关。深入研究DNA序列上与组蛋白相互作用的模体集合即核小体结合模体集合，建立核小体阵列信息学分析理论，对于揭示核小体在基因转录调控、非编码基因识别中的作用机制等相关问题具有重要的生物学意义。本项目将基于人类基因组，提出一个预测理论，预测DNA序列上所有可能的核小体结合模体。分析这些模体的性质，并用当前的实验分析结果进行印证；探讨核小体结合模体在功能位点区域（如转录起始位点等）的分布特征和模体的序列特征；推测与核小体定位和核小体移动相关的模体特征以及他们的组合方式；构造核小体的静态分布图谱；基于不同生物基因组，研究核小体结合模体的进化。

Nucleosome positioning and remodeling are correlated closely with the DNA sequence bias. It is necessary to study the motif set which interacted with histone set in DNA sequence, we call them nucleosome binding motifs, and establish the corresponding analysis theory about nucleosome array. This research has crucial biological meanings to uncover the mechanisms of gene transcription and regulation as well as non-coding gene recognition. We will establish a theoretical method to predict all of the possible nucleosome binding motifs on DNA sequence of human genome and analyze the characteristics of the predicted motif set. The reliability of these motifs will be verified by relative experimental results. The characters of the motif distributions and the motif structures will be analyzed on the sequences flanking different kinds of functional sites (such as transcription start site , etc). The combinational modalities of the motifs referred to nucleosome positioning and remodeling will be researched based on these functional regions. And then, we will try to construct the static spectrum of nucleosome distribution on human chromosomes. Finally, we will study the evolution of nucleosome binding motif set based on different genomes.