哮喘患者气道周围血管数量和面积的增加即血管重塑，是气道重塑的典型特征之一，可导致气道管壁增厚从而引起气道狭窄和气流受限。Th17/IL-17能够促进哮喘气道慢性炎症和气道重塑的进展，但其在血管重塑中的作用迄今未明。最近的一些研究发现Th17/IL-17可以通过诱导血管形成这一病理过程而参与肿瘤、类风湿关节炎等疾病的发病。因此，我们推测Th17/ IL-17也参与了哮喘气道血管重塑的过程。本项目拟研究Th17/IL-17在哮喘气道血管重塑中的作用，探讨Th17/IL-17究竟是通过何种方式（血管形成和/或血管生成）加速血管重塑的进程，并明确具体的下游信号和通路，初步开展以Th17/IL-17为靶点的免疫治疗，可为深入了解哮喘气道重塑的发生机制提供新的线索。

Vascular remodeling，one of the common characteristics in airway remodeling，presented as increased size, engorgement and number of microvessels within bronchial tissue in asthmatic patients and resulted in increased airway wall thickness，finally led to airway narrowing and air?ow limitation. Th17/IL-17 can promote airway inflammation and remodeling that occurs in chronic asthma, but whether they play a causative role in vascular remodeling remains unclear. Recent evidences indicate Th17/IL-17 involve in vascularization in rheumatoid arthritis and tumor, grabbing our attention to investigate the role of Th17/IL-17 in the progression of airway vascular remodeling. Our study will be carried out to confirm how do Th7/IL-17 accelerate airway vascular remodeling: angiogenesis or vasculogenesis or both? Moreover, detect the detail receptor and downstream signaling pathway, preliminarily developed Th7/IL-17-targeted immunotherapy, providing new insight into patholo- gical mechanism of airway remodeling in asthma.