炎症响应型近红外二区光热纳米药物的构建及抗细菌生物被膜感染治疗的研究

批准号:
22005344
项目类别:
青年科学基金项目
资助金额:
24.0 万元
负责人:
赵钰
依托单位:
学科分类:
医用材料化学
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
赵钰
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中文摘要
细菌耐药性问题日趋恶化,细菌对抗生素的耐药性产生速度远超新型抗生素的开发速度。然而现今存在的抗菌材料普遍存在组织渗透深度浅,耐药菌造成的感染难以治愈的问题,因此,迫切需要发展新型非抗生素药物,从根源上解决细菌的抗生素耐药性产生的问题。本项目依据细菌感染微环境的弱酸性特征,制备以酸响应电荷翻转聚合物为壳层,聚吡咯纳米粒子为核心的药物载体并负载抗生素,构建具有近红外二区吸收的光热-抗生素协同纳米治疗剂。系统研究材料结构因素对细菌感染微环境响应及抗菌活性的影响;建立铜绿假单胞菌感染的小鼠肺炎模型,研究该近红外二区光热抗菌材料的组织穿透能力和体内治疗效果,系统揭示该材料的抗生物被膜感染作用规律。该新型抗菌材料的研究有望对细菌生物被膜感染治疗新方法提供重要的实验数据和科学依据。
英文摘要
The resistance of bacteria to antibiotics is growing much faster than the development of new antibiotics. However, the existing antibacterial materials generally have the problem that the tissue penetration depth is shallow, and the infection caused by drug-resistant bacteria is still difficult to cure. Therefore, it is urgent to develop new non-antibiotic drugs and solve the problem fundamentally. According to the characteristics of the bacterial infection microenvironment, this project prepares polypyrrole nanoparticles with acid-responsive charge reversal shell loading antibiotics for photothermal-antibiotic synergy therapy at near-infrared-II region. This project systematically studied the effects of structural factors on the microenvironment response and antibacterial activity. The pneumonia model induced by Pseudomonas aeruginosa was established to study the tissue penetration ability and in vivo therapeutic effect of this near-infrared-II photothermal anti-biofilm material. The anti-biofilm infection effect of the material is systematically revealed. Overall, the study of this new antibacterial material is expected to provide important experimental progress and scientific basis for the treatment of bacterial biofilm infections.
期刊论文列表
专著列表
科研奖励列表
会议论文列表
专利列表
DOI:10.1080/10717544.2023.2177362
发表时间:2023-12
期刊:Drug delivery
影响因子:6
作者:
通讯作者:
DOI:10.1002/mabi.202200430
发表时间:2023
期刊:Macromolecular Bioscience
影响因子:--
作者:Yu Zhao;Jiaying Yang;Danli Hao;Ran Xie;Lingyu Jia;Miyi Yang;Hai Ma;Pengqian Wang;Weipeng Yang;Feng Sui;Haiyu Zhao;Yanjun Chen;Qinghe Zhao
通讯作者:Qinghe Zhao
DOI:10.3389/fphar.2022.860492
发表时间:2022
期刊:FRONTIERS IN PHARMACOLOGY
影响因子:5.6
作者:Hao, Dan-Li;Wang, Ya-Jie;Yang, Jia-Ying;Xie, Ran;Jia, Ling-Yu;Cheng, Jin-Tang;Ma, Hai;Tian, Ji-Xiang;Guo, Shan-Shan;Liu, Ting;Sui, Feng;Zhao, Yu;Chen, Yan-Jun;Zhao, Qing-He
通讯作者:Zhao, Qing-He
国内基金
海外基金
