在肝细胞癌临床治疗效果差、复发转移率高、死亡率高的大背景下，明确肝细胞癌发生发展的分子机制将可为研发新型肝细胞癌治疗策略、克服肿瘤的放化疗抗性、提高肿瘤临床治疗效果具有重要现实意义。肝细胞癌是我国发病率和死亡率均很高的一种恶性肿瘤，其早期诊断难、化疗效果和预后均很差。本项目将基于我们多年对肝细胞癌基本生物学特性、耐药特性等前期研究基础，探究ZNF143/MDIG/CDC6信号通路对肝细胞癌发生发展的影响，具体开展以下三个方面的研究：（1）揭示ZNF143/MDIG/CDC6信号通路关键分子在肝细胞癌的功能；（2）初步阐明ZNF143/MDIG/CDC6信号通路调控肝癌发生发展的分子机制；（3）进行靶向肝癌ZNF143/MDIG/CDC6信号通路的治疗新策略实验性研究。该研究成果将有望为靶向肝细胞癌治疗方案的制订提供重要的实验依据和理论指导。

Under the background of poor clinical treatment, high recurrence and metastasis rate and high mortality of hepatocellular carcinoma (HCC), to explore the molecular mechanism of HCC occurrence and progression will have the important practical significance for developing novel HCC treatment strategies, including overcoming the radiotherapy and chemotherapy resistance of HCC, and improving the clinical treatment effect of HCC. HCC is a malignant tumor with high morbidity and mortality in China. Its early diagnosis is difficult, and the chemotherapy effect and prognosis are very poor. This project will explore the effects of ZNF143 / MDIG / CDC6 signaling pathway on the occurrence and progression of HCC based on our previous researches on the basic biological characteristics and drug resistance characteristics of HCC. The following three aspects will be studied: (1) to reveal the function of key molecules of ZNF143 / MDIG / CDC6 signaling pathway in HCC; (2) to preliminarily clarify the molecular mechanism of ZNF143 / MDIG / CDC6 signaling pathway regulating the tumorigenesis of HCC; (3) to explore novel strategies of targeting ZNF143 / MDIG / CDC6 signal pathway to experimentally therapeutics of HCC. Our results will be expected to provide important experimental basis and theoretical guidance for the development of targeted therapy for HCC.