BAF170是染色质重塑复合物SWI/SNF的核心组分之一，在复合物的组装以及功能调控中发挥着重要的作用。我们在前期预实验中发现BAF170在乳腺癌中高表达，且其表达量与乳腺癌病人病程发展以及病人预后密切相关。细胞实验结果和小鼠实验结果均表明，BAF170在乳腺癌生长中起着促进作用。进一步的分子机制研究结果表明BAF170可能通过PI3K信号通路调控乳腺癌生长。考虑到BAF170在SWI/SNF复合物中的特殊作用， 我们提出假说： BAF170的高表达造成了SWI/SNF复合物对PI3K信号通路基因的调控紊乱，进而导致肿瘤的发生。本项目将围绕这一假说展开系统深入的研究，项目的顺利实施将有助于未来精准治疗BAF170高表达驱动的乳腺癌。

BAF170, a core subunit of the SWI/SNF complex, plays an important role in complex assembly and function regulation of the complex. Our preliminary data showed that BAF170 was overexpressed in breast cancer and high BAF170 expression correlated with cancer progression and poor prognosis of patients with breast cancer. Results of cell functional assays and xenograft mouse models demonstrated that BAF170 promoted breast cancer growth. Further mechanistic study suggested that BAF170 regulates breast carcinogenesis via PI3K signaling pathway. Given the role of BAF170 in regulating SWI/SNF complex, we hypothesized that high BAF170 expression leads to dysregulation of the PI3K pathway genes by the SWI/SNF complex, which induces breast carcinogenesis. This study would be of great importance in developing pharmacological therapeutics in precision treatment for high BAF170 expression-driven breast cancer.