氧化锆陶瓷种植体由于良好生物相容性和美观性成为当今种植修复的研究热点，然而其本身缺乏生物活性，弹性模量高，组织适配性差，导致骨整合性能不足，临床修复效果不理想。如何使氧化锆材料具有稳定生物活性、良好组织适配性是促进骨整合、改善种植修复效果的关键，其中氧化锆表面结构功能化及其成骨性能调控是核心科学问题。本研究提出微纳多孔结构与电活性表面相结合的功能化设计理念，拟采用熔融金属镁为脱氧剂，利用镁、锆、铝元素与氧元素亲和性的差异，构建氧化锆/氧化铝复合陶瓷表面“脱氧”处理体系，通过调节脱氧程度，优化表面形貌及孔壁电荷，制备出具有微纳多孔结构、表面带电的氧化锆陶瓷多重活性表面。重点研究氧化锆基陶瓷的脱氧机理、工艺参数与材料性能的规律性关系，探讨多重活性表面的成骨性能调控机制。本项目建立的氧化锆基陶瓷脱氧处理体系，将使生物惰性陶瓷不再“惰”，为新型功能化陶瓷植入材料优化设计提供新思路。

Zirconia implant with good aesthetic and biocompatibility is becoming a research hotspots in implant dentistry. However, due to its chemical inertness and high elastic modulus, there is poor tissue adaptability and osseointegration, the functionalization of zirconia surface and the regulation of its osteogenic performance are the core scientific problems. Therefore, how to treat the zirconia to obtain the bioactive surface and good tissue adaptability is the key for its successful used in clinic. The purpose of this project is establish the “de-oxygen” system of zirconia alumina compsite ceramic with molten magnesium, based on the attractive force differece of magnesium, zirconium, aluminum with oxygen. The micro-nano porous surface with positive charge will be made through regulate the de-oxygen degree of zirconia and alumina. This study focus on the de-oxygen mechanism of zirconia based ceramic, the regular relationship of treatment parameter and material properties, the osteogenic performance of multi-active surface. The inert zirconia based ceramic will no longer inert when meeting the de-oxygen system. This project will provide a new idea for the surface treatment of the implanted materials.