12%～57％的50岁以上人群有明显口腔干燥症状，成为严重影响老年人生活质量的重要问题，目前治疗多采用类胆碱或肾上腺素药物，但是副作用大且不能长期用药。传统中药在治疗口腔干燥方面具有较好的效果，副作用小，如丹参和麦门冬，但是其对唾液腺的作用机理还未阐明，而且在口腔内难以维持长久的有效浓度。本课题重点研究丹参和麦门冬刺激唾液分泌的作用机制，明确药物浓度与唾液分泌量的量效关系；根据中老年牙列缺损发病率高、常需佩戴可摘义齿的特点，拟设计制备可缓释丹参和麦门冬的义齿黏附剂，研究两种中药成分的缓释动力学过程，通过调整义齿黏附剂缓释微球的大小及添加量调控丹参和麦门冬的缓释速度，通过研究缓释微球对义齿黏附剂物理机械性能的影响，实现可稳定释放有效药物浓度且物理机械性能优良的义齿黏附剂。本课题的研究成果将为解除老年口腔干燥患者的症状、增加义齿舒适度、防止继发炎症、提高生活质量提供创新性解决方案。

There is 12～57% of population 50 years or older has dry mouth complaints. Dry mouth is becoming a severe problem affecting living quality of old people. The common used drugs----Pilocarpine and Cevimeline have serious adverse reaction. Actually, Chinese traditional medicine has excellent effective for dry mouth, such as DanShen and Maimendong. However, it is still not yet clear about the mechanism of promoting salivary secretion of both medicine, and it is difficult to maintain the effective drug concentration. The present study is investigate the promoting salivary secretion mechanism of Danshen and Maimendong, explicit the relationship of drug concentration and salivary secretion amount; the denture adhesive with sustained-releasing Danshen and Maimendong will be prepared based on the fact that old people often need restore with removable denture. The release kinetics of both drug and effect on the mechanical properties of denture adhesive will be examined. Finally, the excellent denture adhesive with sustained-releasing effective drug concentration will be developed. The result of this study will be provide a new way to treat dry mouth and increase denture comfort.