脑外伤的发生伴随着脑组织的形变和应力产生，其量化分析和模型建立对研究成伤机制具有重要意义。然而，外力作用下脑组织在颅内相对运动情况，以及脑组织与颅骨间的生物力学边界状态尚不清楚。申请人前期研究对无损伤外力作用下脑组织的在体位移和形变进行了初步的定量测试，并对脑组织的边界条件对其形变的约束作用开展了定性分析。因此，我们提出脑组织颅内的固定与连接状态，即脑组织的生物力学边界条件对脑组织的颅内相对运动和形变具有重要影响，对脑外伤的致伤起到关键作用。本项目采用磁共振快速影像技术，对人脑组织在不同幅度轻微碰撞情况下脑组织的在体动态响应进行测量，建立脑组织有限元计算模型并对脑组织的生物力学边界条件开展优化分析。脑组织的颅内相对运动和生物力学边界条件的分析可以为确定成伤机制，构建准确的脑组织的计算模型提供科学依据，对有效的预测与防护脑外伤具有重要意义。

Quantitative analysis of the stress and strain of the brain in traumatic brain injury (TBI) is important to understand the injury mechanism. However, the brain motion and the biomechanical boundary conditions of the brain are still largely unknown. Our preliminary studies have measured the displacement and strain of the brain under external forces in non-injury conditions. Qualitative analysis of the constraint effect of the brain-skull interface was also carried out. Therefore, we proposed that the physical connections between the brain and skull, which represent the biomechanical boundary conditions of the brain, could greatly influence the motion and deformation of the brain and are keys to inducing TBI. In this study, we propose to use MR fast imaging techniques to acquire the dynamic response images of the brain during different mild impact conditions, and to establish a finite element model to optimize the the boundary conditions of the brain. The quantified relative motion of the brain and the brain boundary conditions will help understand the injury mechanism, improve the current brain computational models, and are important for TBI prediction and prevention.