随着肿瘤分子影像研究的不断深入，单一模式的成像效果往往不能满足临床或预临床研究的要求，多模态信息融合越来越受到人们的重视。本课题将针对多模态分子影像技术这一研究领域，以结直肠癌这一恶性肿瘤为研究对象，开展靶向肿瘤凝集素（Lectin）受体的核医学与光学双模态分子影像及放射靶向治疗研究。设计、合成一批双模态分子探针，通过选择不同药代动力学修饰分子（PKM），评价其用于结直肠癌SPECT早期诊断、光学导航手术及放射靶向治疗的可能性；同时探索出一套核医学/光学双模态分子探针的设计规律，为今后多模态分子影像探针的研究提供理论参考。

With the advances in the research field of tumor molecular imaging, single modality images can not provide all necessary information for preclinical and clinical studies. Instead, multimodality fusion imaging is attracting an increasing interest for both clinicians and scientists. In this proposal, Lectin-targeted dual modality (nuclear/optical) molecular imaging of colorectal cancers by will be performed. A series of dual-modality molecular imaging probes will be designed, synthesized, and optimized by selecting different pharmacokinetic modifying (PKM) linkers. The possibility of using these molecular probes for early SPECT diagnostic imaging and optical imaging-guided surgery and radio-targeted therapy of colorectal cancers will be investigated. The standard rule for designing dual nuclear and optical imaging probes will also be explored. This study would provide important information for the development of other multimodality molecular imaging probes.