降低肿瘤死亡率，提高生存率，不仅需要实现肿瘤的早期检测，而且还需要实现肿瘤的精确诊断，从而有效降低早期诊断的假阴性率和假阳性率。多模态分子影像技术由于整合了多种成像技术的优势，能够在看得早的同时，实现看得准，将成为肿瘤早期精确诊断的有力工具。本项目将研究光学-核素-CT多模态分子影像融合方法与技术，实现肿瘤的早期精确诊断。通过光、放射性同位素、X射线在复杂生物体中特异性传输的研究，创建基于组织特异性的多模融合成像方法和模型，发展生物体中软组织和内脏器官的非刚性形变校正技术，研发特异性的器官快速分割与多模影像精确配准方法和技术。此外，本项目将以荷瘤动物模型为研究对象，探索光学-核素-CT多模态融合分子影像技术在肿瘤早期精确诊断中的应用，建立肿瘤早期精确诊断的多模影像评价标准，为肿瘤等重大疾病发生发展机理的研究提供新方法与新技术。

In order to reduce cancer mortality and improve survival, not only early detection but also accurate diagnosis of the tumor is required to effectively reduce the false negative rate and false positive rate of early diagnosis. Multimodality molecular imaging can accomplish accurate diagnosis at early stage of diseases due to fusion of a variety of imaging techniques, which has become a powerful tool for early and accurate diagnosis of cancer. This project will establish multimodality molecular imaging fusion methods and techniques to achieve early and accurate diagnosis of can based on fusion of optical, radionuclide, and CT imaging information. Multimodality fusion methods based on tissue specificity will be developed by the propagation theory research of different particles in complex organisms. Non-rigid deformation correction, fast segmentation, and precise registration between different imaging modalities are also studied in this project. The above methods and technologies will be validated using tumor-bearing small animal models and employed for early and accurate diagnosis of cancer. Overall, this project will provide new methods and novel techniques for the research of occurrence and development mechanism of fatal diseases like cancer.