基于“阳化气，阴成形”理论探讨理冲生髓饮有效组分治疗卵巢癌的生物动力学机制研究

卵巢癌严重威胁女性健康，发病率居女性生殖系统恶性肿瘤第3位，死亡率居妇科恶性肿瘤之首。课题组前期研究表明“温煦肾阳，搜剔胞络瘀滞”法对卵巢癌治疗具有疗效，在此基础上，提出“阳化气，阴成形”为人体正常生理过程，阳化气不足而阴成形太过，则阴阳失衡，致瘀结生殖之所，是卵巢癌发生的深层病因病机。结合生物动力学研究视角，提出假说：卵巢癌的发生与演变是“阴”和“阳”两种细胞因子群相互作用与竞争的过程。本项目拟利用具有温阳功效的理冲生髓饮有效组分，通过动物体内、体外实验，观察卵巢癌“阴”和“阳”相关细胞因子表达，并通过构建Lotka-Volterra生物动力学方程模型对其“阴”“阳”相互作用关系做出诠释和把控。本项目的意义在于从“阳化气，阴成形”的理论出发，阐明基于该理论治疗卵巢癌背后的生物动力学机制，期望为卵巢癌的防治提供新的启发和指导，进而发展和丰富中医传统理论，弘扬祖国中医药传统文化。

Ovarian cancer is a serious threat to women's health. The incidence rate is third in female genital system and the mortality rate is the highest in gynecologic malignancies. The preliminary study of the research group shows that the method of " warming kidney yang, searching and eliminating stasis and stagnation " has curative effect on the treatment of ovarian cancer. On this basis, it is further proposed that " Yang Hua Qi, Yin Cheng Xing " is a normal physiological process of human body. If the Yang Hua Qi is insufficient and the Yin Cheng Xing is redundancy, then the imbalance of yin and Yang will lead to the blood stasis in the reproductive system, which is one of the most important causes of ovarian cancer. From the perspective of biodynamics, the hypothesis is put forward that the occurrence and evolution of ovarian cancer is a process of interaction and competition between "Yin" and "Yang". In this project, Effective components of Li Chong Sheng Sui Yin, is used as an experimental drug for this project. Vivo and vitro experiments are conducted to observe the expression of cell factors of "Yin" and "Yang" in ovarian cancer, and to explain and control the interaction between "Yin" and "Yang" through the construction of Lotka Volterra biodynamics equation model. The significance of this project is to clarify the biodynamics mechanism behind the treatment of ovarian cancer based on the theory of " Yang Hua Qi, Yin Cheng Xing ", hoping to provide new inspiration and guidance for the treatment of ovarian cancer, and then develop and enrich traditional Chinese medicine theory.