多色19F磁共振成像可视化技术监测肿瘤微环境构成及其动态变化

本项目聚焦“恶性肿瘤微环境演进的可视化”这一方向的研究需求，拟发展多色19F磁共振成像可视化技术监测肿瘤微环境构成及其之间相互作用与动态变化。肿瘤微环境对于澄清肿瘤形成和演进过程中的关键机制、实现肿瘤的准确诊断和有效治疗具有重要意义。然而，传统的成像技术应用于生物活体时存在局限，无法满足肿瘤微环境研究对其构成进行原位深层追踪的需求。因此，发展一种非侵入式的高效实时深层成像监测方法，是当前肿瘤微环境研究亟待解决的重大科学问题。针对这一科学问题，我们拟构建高性能的19F磁共振成像探针为化学工具，发展多功能和高灵敏的多色19F磁共振成像可视化技术，对肿瘤微环境构成进行实时成像监测，实现肿瘤微环境构成及其之间相互作用与动态变化的可视化定量分析，从而为厘清肿瘤免疫、肿瘤代谢与肿瘤演进的关系、揭示肿瘤演进的关键调控机理提供重要证据，为发展精准的肿瘤诊断技术和可靠的肿瘤个性化治疗夯实基础。

We are focusing our research on “visualization of the development of malignant tumor microenvironment” and plan to develop a multi-color 19F magnetic resonance imaging (MRI) visualization technique for monitoring the components of tumor microenvironment (TME) and their interactions and dynamic changes. The studies of tumor microenvironment are very important for clarifying critical details in tumor initiation and development and realizing accurate diagnosis and efficient treatment of tumor. However, due to their limitations in in vivo imaging, traditional imaging techniques fail to meet the needs of current studies on TME in the in situ detection and monitoring of TME components. It is of urgent demand to develop a high-performance non-invasive technique with optimal penetration depth for in situ imaging and tracking of TME components. To address this demand, we plan to construct high-performance probes for 19F MRI and develop a multi-functional highly sensitive multi-color 19F MRI visualization technique. This technique will enable in situ imaging, tracing and quantitative visualization analysis of TME components and their interactions and dynamic changes, which is critical to the exploration of the relationships among tumor immunity, tumor metabolism, and tumor development and the key regulating mechanisms during tumor development and therefore lays a foundation for the development of accurate diagnosis and reliable personalized treatment for tumor.