生物响应磁共振成像探针的构建及活体氧化/还原应激过程成像监测研究

生物体内的氧化/还原应激过程研究对于生理学和病理学的研究具有重要意义，在相关疾病的诊断和治疗方面亦具有参考价值。然而，传统的研究手段应用于活体层面时存在局限性，无法满足当前氧化/还原应激研究在活体深组织内追踪活性分子的需求。因此，发展一种高性能的、可以应用于活体层面的非侵入式深层成像监测手段，是当前氧化/还原应激研究亟待解决的问题。针对这个挑战，我们拟总结归纳生物响应磁共振成像探针的构效关系，以此为指导设计合成多种高性能的探针作为化学工具，发展高灵敏度和高准确性的生物响应磁共振成像方法。生物响应磁共振成像有望实现对活体深组织内的活性分子进行实时成像监测，为探索氧化/还原应激过程的重要节点和解析相关过程的关键细节提供科学证据，从而为厘清特定的氧化/还原应激过程奠定坚实基础。在此基础上，我们还计划将生物响应磁共振成像用于疾病诊断，为特定疾病的灵敏准确诊断提供解决方案。

Studies on oxidative/reductive stress-related processes in organisms are important to physiological and pathological researches as well as diagnosis and therapy of relevant diseases. Traditional research techniques have some limitations on living subjects, failing to satisfy the need of current oxidative/reductive stress studies for in situ detecting and tracing bioactive molecules in deep tissues. Therefore, it is of urgent demand to develop a high performance non-invasive imaging and monitoring technique with deep penetration, which can be applied to living subjects. To address this challenge, we plan to start with investigating the structure-performance relationship of bio-responsive probes for magnetic resonance imaging (MRI). Based on the relationship, we will design and synthesize multiple high-performance probes for bio-responsive MRI, which will be used to study various oxidative/reductive stress-related processes. Bio-responsive MRI will enable in situ detection and tracing of bioactive molecules in living subjects. This is of great help to the exploration of the key nodes in oxidative/reductive stress-related processes and the revelation of the critical details, which lays a solid foundation for clarifying these processes. On top of this, we plan to utilize bio-responsive MRI for diagnosing related diseases, which will hopefully provide solutions for sensitive and accurate diagnosis of these diseases.