生物有效性涵盖有机污染物的赋存、传质、生物膜吸收等作用或过程(统称为生物有效性过程)，通常是污染物生物降解与修复的限制性因素。主体化合物如环糊精，可通过包合作用提高污染物生物有效性，用于环境污染修复。现有研究受限于生物膜吸收资料缺乏、污染物选择单一等，难以阐明主体化合物对污染物生物有效性过程的影响机制。本研究基于生物有效性过程概念剖析，拟开展土壤模拟或现场测试，采用经典的环境化学实验技术并引入药物学的生物膜渗透测试技术，在排除主体化合物自身对环境扰动效应的前提下，考察它们对常见有机污染物脱附、模拟生物膜渗透、土壤降解或生物富集的影响，分别辨析它们对污染物环境赋存(含环境传质)、生物膜传质、生物活性的影响效应。同时，统计分析这些影响效应与污染物化学结构的关联及存在的化学多样性。本研究涵盖了生物有效性过程概念中的全部作用或过程，预计能阐明主体化合物对污染物生物有效性过程的调控机制。

Bioavailability processes of organic pollutants involve a variety of individual physical, chemical, and biological interactions or processes, including speciation, mass transfer, and permeation across biological membrane. They have been recognized as limiting factors to biodegradation and bioremediation of organic compounds in soils or sediments. Host compounds (e.g., cyclodextrins) are increasingly applied to bioremediation of organic pollutants by improving their bioavailability. It is attributable to well recognized inclusion complexation through which organic pollutants are accommodated into the cavity of host compounds and form water soluble complexes. However, mechanisms by which host compounds mediate bioavailability processes of organic contaminants are poorly understood. To answer this question, both laboratory and field studies will be conducted about effects of host compounds on desorption, permeability, and biological reactivity of typical organic pollutants (e.g., pesticides and PAHs). Firstly, the experiments about adsorption and environmental stability of host compounds themselves and effects on soil microbes will be carried out to determine application rates of host compounds beyond which host compounds can lead to adverse effects on biological properties of soils. Secondarily, host compounds below these levels will be chosen for the following experiments including inclusion complexation, desorption, permeation across artificial biological membranes, and biological activities (e.g., soil degradation and earthworm bioconcentration). These experiments are aimed to investigate effects of host compounds on speciation, environmental/membrane transfer, and apparent bioavailability of structurally different organic pollutants. Finally, differences in inclusion complexation of host compounds with organic pollutants will be analyzed to classify these pollutants. And statistics analysis about effects of host compounds on desorption, permeability, and biological activities of organic pollutants will be done to reveal chemical diversity in mediation effects of host compounds. Overall, all the experiments are designated to obtain the information about effects of host compounds on speciation, environmental transfer, membrane transfer and biological activities of organic pollutants. These information are related to all the interactions or processes involved in bioavailability processes of organic pollutants, from the viewpoint of the definition "bioavailability processes of organic pollutants" advocated by the Annual Report of National Research Council. So, it is feasible to reach the goal of this project to reveal mediation of host compounds in bioavailability processes of organic pollutants.