具有近红外SPR效应的纳米晶体已被广泛用于癌症光治疗试剂研究。Yolk-Shell型AuNR@Cu2-xS纳米晶体由于贵金属AuNRs与半导体Cu2-xS二者间的等离子耦合作用能够提高光治疗活性且兼具空腔载药等优势而备受关注。由于AuNRs与Cu2-xS的SPR效应分别与其各自晶面原子排布状态密切相关，改变AuNRs和Cu2-xS的晶面种类可以调节AuNRs和Cu2-xS间的等离子耦合作用，进而提高光治疗效果。然而目前对Yolk-Shell材料光治疗性能的调控仅限于改变Yolk和Shell的相对尺寸，通过晶面进行调控鲜有报道。本项目拟以具有不同Yolk-Shell晶面组合的AuNR@Cu2-xS 纳米晶体为模型，从非生物、细胞、动物水平探索不同晶面组合对纳米晶体光治疗性能的影响关系，从分子水平阐述光治疗性能对纳米材料晶面组合的依赖性机理，为开发晶面介导的光治疗复合纳米试剂提供理论依据。

Nanocrystals with surface plasmon resonance (SPR) induced near-infrared (NIR) absorption properties have been widely explored as cancer phototherapeutic agents (photothermal agent and photosensitizer). Due to the SPR coupling between plasmonic noble metal Gold Nanorods (AuNRs) and semiconductor Copper Sulfide (Cu2-XS), facile AuNR@Cu2-XS yolk–shell nanocrystals present efficient phototherapeutic property, while the void in the core–shell also hold great promise for drug delivery. SPR properties being affected by the organization of surface atoms, i.e. facet of nanocrystals, SPR coupling between core and shell could be adjusted by facet property of AuNRs and Cu2-xS respectively to improve the phototherapy effect. However, most of the work has been done to improve phototherapy effect by adjusting the size of york-shell structure or by adjusting the yolk/shell molar ratios. Little work has been done to enhance the photothermal and photodynamic properties of yolk-shell nanocrystals by tuning the facet property of york-shell structure. Here we propose to apply AuNR@Cu2-XS with tunable yolk-shell facets for cancer phototherapy. This study will provide not only the relationship between the phototherapy efficient (in vivo and in vitro) and facets of nanocrystals, but also the molecular mechanism of the facet-dependent phototherapeutic property of yolk-shell nanocrystals and rational facet design tools for phototherapeutic nano-agents.