参附注射液阻断Nogo1-NgR促进心肺复苏后脑组织神经轴突再生的机制

全世界心肺复苏术已逐年普及和提高，但患者的存活率和生存质量仍仅有10%以下，神经系统评估是存活者常规评估的主重环节。多年研究表明，脑缺血后神经元的修复与中枢神经系统抑制因子阻碍神经再生密切相关，Nogo1是最为强烈的神经纤维再生抑制因子,通过与其受体（NgR）等结合传导抑制信号RohA，阻碍神经再生。近期研究已在心肺复苏后大鼠脑白质和海马区发现Nogo-mRNA和NgR的变化表达，为神经功能恢复提供有效的作用靶点。参附注射液为“回阳救逆”第一古方，心脑缺血再灌注损伤应用取得一定成果。本研究通过参附注射液对心肺复苏后大鼠脑组织Nogo-A受体（NgR）表达及神经功能再生的影响，从中枢神经再生抑制信号表达的新角度，探讨参附注射液促进神经功能修复的机理，为参附注射液的临床应用提供新的理论与方法，为中西医结合抢救心脏骤停奠定基础。

Despite improvements in cardiopulmonary resuscitation (CPR) quality, survival rates following in-hospital and out-of-hospital cardiac arrests remain disappointingly low<10%. Cerebral injury caused by ischemia and hypoxia during prolonged cardiac arrest is compounded by reperfusion injury.Neurocognitive deficits remain a significant source of morbidity in survivors of cardiac arrest.It has been reported that the expression of messenger RNA (mRNA) and protein in brain.tissue increases significantly after damage, and NgRhas been proposed to play a central role in signaling myelin inhibition .Shen-Fu injection (SFI) following cardiac arrest exhibits neurological effects, but its effect on neurological dysfunction is unclear. This study sought to investigate the protective effect of SFI on nerve axonal regenerative in a rat model of cardiac arrest.