肺癌是我国发病率和死亡率第一的恶性肿瘤，发展精确的诊断方式和微创、高效的治疗方法是攻克肺癌的关键。本项目拟以石墨烯量子点(GQD)负载诱导氧化应激的药物和光敏剂，对肺癌进行精确诊断和高效治疗。通过EPR效应、主动靶向和光热力学效应提高探针在靶细胞中的浓度，并利用探针在靶细胞中由“off”到“on”的磁共振和荧光信号，降低背景噪音，提高检测准确度。通过靶细胞中富集的药物，以氧化应激提高光动力学治疗效率，使光热力学疗法、光动力学疗法和生物氧化疗法彼此相互促进，用多种手段提高疗效。这种双模态探针集检测和治疗功能为一体，可实时监测治疗过程中肿瘤的发展情况以便及时调整治疗方案，为肺癌的可视化治疗提供一种新方法。

As a malignant tumor with the highest morbidity and mortality in China, lung cancer has been given rising attentions along with environmental deterioration. Development of comprehensive and reliable technique for early diagnosis and therapy are the key to cure lung cancer. In this project, fluorescent graphene quantum dots (GQD) are introduced as vehicles to load redox biological drug and photosensitizer for accurate diagnosis and efficient treatment of lung cancer. The concentration of the designed probe is increased in lung cancer cells through EPR, active targeting and photothermal effect. Meanwhile, the fluorescent and MR signal will turn on in targeted cells. Signal noise will be decreased by the above two designations, thus, the accuracy of lung cancer diagnosis is increased. Moreover, reactive oxygen species resulted from the reaction between redox active drug and cellular reducing metabolites lead cancer cells more impressionable to photodynamic therapy from photosensitizer. The therapy efficiency enhances by the combination of photothermal therapy, photodynamic therapy and biological redox therapy. The designed multi-model probe combines diagnosis and therapy in a singlet vehicle, which could monitor the tumor progression and then improve the treatment in time. Hence, the project will provide a new way to imaging guided and combined lung cancer therapy.