苯并咪唑类农兽药之间性质差异大，在复杂基质中难以被同时提取和检测。氧化镍对咪唑环骨架有特异作用，但迄今鲜少有应用氧化镍对苯并咪唑类农兽药进行分离富集的研究。针对这一研究空白，本项目拟开展基于氧化镍材料的食品中苯并咪唑类农兽药化合物及其代谢物的简单、快速、高通量、高选择性、高灵敏度的分析新方法、新技术的研究。通过液相沉积的方法，设计、制备以磁颗粒和氧化硅纤维为基底的两种新型纳米氧化镍涂层萃取材料；研究新材料对咪唑类化合物的选择性萃取作用原理，结合色谱-质谱联用分析技术，构建能快速测定复杂食品基质中苯并咪唑类农兽药多残留的灵敏检测技术平台；并在此基础上进一步探寻苯并咪唑类农兽药新的代谢转化产物以及探讨其可能的代谢机理。项目的实施将为食品安全监控及咪唑类化合物的代谢分析提供新的分析技术手段。

Benzimidazole pesticides and veterinary drugs are difficult to be simultaneously enriched and detected due to their different properties. Previous studies showed that nickel oxide (NiO) has specific interaction towards midazole rings. However, NiO has been hardly applied in the enrichment of benzimidazole pesticides and veterinary drugs in foods. In this project, we aim to develop simple, rapid, high throughput, highly selective and sensitive methods and techniques for benzimidazole residues analysis in foods. We plan to prepare novel extraction media of nickel oxide (NiO) nanoparticles coated in the surface of magnetic particles and silica fiber based on liquid phase deposition method. The selective extraction mechanism of these materials towards benzimidazole compounds will be studied in details. And Rapid and sensitive analytical methods for the detection of residue of benzimidazole pesticides and veterinary drugs in foods will be established using the novel extraction media. In addition, the metabolites of benzimidazole pesticides and veterinary drugs in foods will be explored to elucidate the metabolic mechanism of benzimidazole pesticides and veterinary drugs. The developed platform will provide new methods for the monitoring of benzimidazole compounds and their metabolites in foods and provide new technology for the research about the metabolism of benzimidazole compounds.