在新反应的发现过程中，对一些已经获得广泛研究并取得共识的反应提出不同的设计反应的思路来合成新的化合物具有重要的理论和实践意义。本项目拟通过加入竞争试剂策略性地阻止Jacobsen-Katsuki环氧化反应途径，通过精准控制化学选择性来发展基于锰盐催化的新反应，合成一系列在有机合成以及化学生物学研究中有应用价值的目标分子。这些研究主要包括两大部分：（1）发展基于酰化叠氮化、酰化氰基化、酰化三氟甲基化的简单烯烃转化、二烯环化、多烯环化以及分子内环化的新反应；发展基于不饱和酰胺类化合物的酰化叠氮化反应以及分子内脱羧环化叠氮化反应，用以上这些方法简洁高效合成具有潜在应用价值的链状多肽以及环肽衍生物;（2）不对称自由基反应的探索研究。这些新方法学将对相关领域的研究和应用作出有意义的补充和发展。

In the process of discovering new reactions, it has both theoretical and practical significance to provide different insights into designing new reactions from well established reaction systems. By adding competitive new reactants to strategically block Jacobsen-Katsuki epoxidation pathway, this project aims at developing a range of manganese-catalyzed chemo- and stereoselective reactions through precisely controlling chemoselectivity. A number of valuable molecules will be produced which are significant target molecules in the research areas of organic synthesis and chemical biology. This project can be divided into two parts: (1) the development of new reactions including acylazidation, acylcynation and acyltrifluoromethylation of unactivated olefins, diene and polyene and the investigation of acylazidation and decarboxylative azidation reactions based on unsaturated amides, which could be applied in the concise synthesis of valuable linear and cyclic peptides; (2) the exploration of asymmetric radical version of these reactions. These methods will make a significant complementation to the related research fields.