头皮白癜风目前缺乏明确有效的治疗手段，且发病机制还不清楚。我们前期通过毛发移植治疗头皮白癜风，发现表皮复色满意，毛发仍然保持白色；行毛囊部位黑素细胞系分化调控相关基因免疫组化染色，发现毛囊神经嵴干细胞定向分化为黑素细胞的通路受阻。PAX3是具有双向调控黑素细胞生成功能的多条信号通路中的关键因子，结合我们前期研究结果，推测其在白癜风发病过程中起重要调控作用。本研究旨在探讨和明确PAX3及其相关信号通路在人类毛囊神经嵴干细胞定向分化为成熟毛囊黑素细胞的作用和机制，同时评价UVA1在头皮白癜风的治疗效果。这些研究对于拓展和完善白癜风的发病机制理论体系,寻找合适的治疗靶点都具有重要的理论价值和深远的临床应用前景。

Scalp vitiligo is resistance to treatments. The pathogenesis is not clear now. Patients of vitiligo involving scalp were treated by hair transplantation.Our early with hair transplantation in the treatment of scalp vitiligo, skin color was found satisfactory, still keep hair white; for hair follicle melanocyte differentiation related genes by immunohistochemical staining found neural crest stem cells differentiate into melanocytes blocked pathway. PAX3 is a key factor in the regulation of the formation of a number of signaling pathways, and combined with the results of our previous studies, it is speculated that it plays an important regulatory role in the pathogenesis of vitiligo..This research focuses on the role and mechanism of PAX3 and related signaling pathway in the differentiation of HF-NCSC to mature hair follicle melanocytes ；evaluation on UVA1 in the treatment of scalp vitiligo ，which have important value on the theoretical system of the vitiligo pathogenesis and clinical application prospect by therapeutic target finding.