多环型呫吨酮类天然产物的全合成研究

多环型呫吨酮类天然产物是结构复杂、生物活性显著的一类天然产物。按照此类化合物的结构特点，可将其分为citreamicin类、FD-594类、kibdelone类和albofungin四类。在前期工作中，申请人课题组已经完成了kibdelone类天然产物的合成，此次申请将着重研究：FD-594类、albofungin类天然产物的合成，具体包括其代表性天然产物：FD-594、kigamicin A-E等，这些天然产物均具有重要的生物活性，因此，开展相关天然产物及类似物的合成研究，具有重要的科学意义和潜在应用价值。此项目拟采取汇聚式合成策略，实现单体的偶联，为此类天然产物的构效关系等药物化学研究奠定基础。

Polycyclic xanthone natural products (PXNPs) are a family of polyketides with complex structure, excellent bioactivities and great potential for drug discovery. It can be divided into four subgroups, including citreamicin-type, FD-594-type, kibdelone-type and albofungin-type, based on their structural features. The applicant has accomplished and reported the synthesis of kibdelone C. This application will focus on the total synthesis of FD-594-type and albofungin-type PXNPs, including FD-594、kigamicin A-E, which show potent biological activities. Therefore, total synthesis of these natural products and their derivatives has great significance to both academic field and potential applications in pharmaceutical. This research program will carry out a convergent total synthesis of this family of natural products which will lay a solid foundation for the structure-activity relationship and related medicinal chemistry studies.