手性富碳大环化合物阻转异构体的合成、调控及超分子化学研究

手性物质的研究是当代化学的核心内容。合成富碳材料（如富勒烯、碳纳米管、石墨烯（炔）等）中精确裁剪的特定大环基元片段即富碳大环分子，被认为是采取自下而上策略，合成具有特定结构和功能的富碳分子材料的重要物质基础。上述领域交叉融合，手性富碳大环分子的研究成为热点，但发展目前面临以下问题：（1）缺乏特定手性异构体选择性合成方法的探讨和手性相关超分子化学性质探究；（2）该类大环结构和性能的调控手段及规律的探究尚待发展；（3）交叉学科领域应用报道有限。本项目提出构筑系列具有非对映阻转异构体的刚性手性环芳烃类富碳大环化合物，利用合成方法调控，结合简便的外部刺激（如加热）手段，探究新型手性富碳大环化合物非对映和对映阻转异构体的手性选择性合成和相互转化及其规律。进一步探究利用上述不同手性异构体构建扩展π体系手性拓扑异构体，开展手性分子识别和手性超分子自组装探究，并开发其在智能材料和信息工程等交叉领域的应用。

Chiral material study is the core of current chemistry. The study of tailor made macrocyclic fragments in carbon-rich materials (e.g., fullerenes, carbon nanotube, grapheme or graphyne, etc.) stimulate interests in different fields. These macrocycles (named as carbon-rich macrocycle herein) were considered as the important material basis to achieve carbon-rich molecular materials with special structures and properties via bottom-up approach. The combination between chirality and carbon-rich macrocycle induces chiral carbon-rich macrocyle study as a hot research filed. There are still some science-related issues in the chiral carbon rich macrocycle as shown below: (1) the selective synthetic methodology to obtain single chiral isomer of carbon-rich macrocyle, and related chiral supramolecular chemistry exploration are still limited; (2) after the generation of the maclocycls directly from the synthesis, the structure/property regulation strategies and their rules are lacking;（3） the usability exploration in the interdisciplinary research area is under development. In this proposal, novel rigid cycloarene macrocycle with non-canonical atropisomers was designed. In this proposal, novel rigid chiral cycloarene macrocycle with non-canonical atropisomers was designed. The study combines the selective synthetic methodology and the facile regulation strategies (such as heating) and related rules. Both could induce diastereoselective and/or enantioselective chiral non-canonical atropisomers and their transformation. Furthermore, the chiral macrocycles with different isomers could be used for the construction of expanding carbon-rich structures with different chiral topology via post-modification strategy, chiral molecular recognition, and supramolecular self-assembly with special chirality and related properties. Moreover, the usability of these chiral macrocycles in the interdisciplinary research area (e.g., smart materials and information technology) would be developed.