结合超分子化学中的手性大环化合物和含有多个氮杂环卡宾前体基元（NHCH+）的大环化合物研究，本项目拟设计和合成含有多个NHCH+结构基元的新型手性大环化合物（CM-NHCH+），以之针对三个重要科学问题开展研究：（1）手性传递放大的机制与规律：以CM-NHCH+为构筑基元，实现新型手性自组装体系及相关功能材料，进行相关内在规律的总结和深入探究；（2）不同镜像异构体的手性效应与功能及其在新药靶和靶向干预策略的应用：CM-NHCH+与手性生物活性分子包括其对映异构体进行相互作用，探究系列上述分子及复合物的手性效应与功能及其在疾病诊疗中的应用；（3）单一镜像异构体的精准高效构筑；CM-NHCH+可参与具有手性调控、传递或放大等功能的分子催化体系，进行具有重要生理活性的手性小分子的高效高对映选择性催化。本项目目标是开发该类未见报道的新型主体分子及手性相关新反应及新材料，并发展到实际应用的范畴。

Combining the studies of chiral macrocycles, also macrocyclic hosts containing multi N-heterocyclic carbene (NHC) precursors (NHCH+), this proposal involves design and synthesis of chiral macrocycles containing multi NHC precursor units (CM-NHCH+), and further explore their contribution to solving the following three scientific problems: (1) the mechanisms and rules of chiral amplification; CM-NHCH+ can co-work with other building blocks to construct chiral supramolecular self-assembly structures and related materials, which lead to delve into the internal rules. (2) Chiral effects and properties of different enantiomers, and their usability in developing the strategies involving unexplored drug targets and interference targeting: CM-NHCH+ also can recognize chiral bioactive molecular guests (e.g., chiral drug small molecules and critical macrobiomolecules such as DNA, RNA and proteins), and further modify their chiral structures and properties of the guests. The study can be used for the chiral guest related illness detection and treatment. (3) The single enantiomer construction with high efficiency and accuracy: CM-NHCH+ can act as supramolecular catalyst of the asymmetric reaction to generate chiral small molecule with high efficiency and perfect chiral selectivity. The proposal objective is to study far less developed macrocyclic host CM-NHCH+, and explore their related unusual asymmetric reactions and novel chiral material for practical application.