NMDA受体介导的兴奋性毒性对慢性氟中毒仔代神经发育及学习记忆的影响

地方性氟中毒分布广泛，危害严重。贵州省是典型的燃煤污染型氟中毒病区，我们前期对氟病区 8-12 岁学龄儿童进行氟中毒及智力水平调查，发现病区儿童氟中毒情况较严重，且智力水平明显下降，提示儿童体内高氟负荷会对智力发育产生损伤作用，但目前慢性氟中毒对神经系统及智力发育的损害作用机制仍不清楚。. 本项目通过构建体内、体外氟中毒模型，以神经系统发育和学习记忆关系密切的兴奋性氨基酸及其受体介导的兴奋性通路为主要研究靶点，研究慢性氟中毒仔代生长及神经行为发育；兴奋性神经递质转运体、兴奋性递质受体相关转运体改变；以及其与学习记忆功能损伤关系等。探讨慢性氟中毒对仔代神经系统发育及智力低下的分子损害机制。

Endemic fluorosis is a disease distributed widely and exerts toxiceffects on many tissues and organs of human body. Guizhou province is a typical coal-burning endemic fluorosis area, we had investigated fluorosis and intelligence of children aged 8 to 12, found that the status of children’s fluorosis were serious, and the level of intelligence decreased significantly,that reminded the hight fluoride would produce damage effects on mental development, but the mechanism still not clear. . The purpose of the project is to study the relationships of the offsprings growth and neurobehavioral development, excitatory neurotransmitter,receptors and related transporter changes, and deficit in learning and memory by building a model of fluorosis in vivo and in vitro. To reveal the molecule mechanisms of the neurogenesis damages and the decreased ability of learning and memory induced by chronic fluorosis.