动脉粥样硬化(AS)已成为全球严重公共卫生问题。通过调控巨噬细胞极化稳态系统来改善AS，是AS防治的全新策略。但是运用这一策略的主要障碍在于：在巨噬细胞被激活的过程中，对调控巨噬细胞极化的分子机制仍不清楚。丹参是我国著名中药，传统药用部位是根及根茎，具显著的心血管活性。在提供大量根及根茎时，地上部分均被废弃。然而，我们前期研究已证实，丹参地上部位含有丰富的三萜类化合物，并且其总三萜能通过调控巨噬细胞极化稳态系统改善AS。在此背景下，本项目结合现代化学，药理学及蛋白质组学等多学科手段和方法，充分考虑中药多成分多靶点的作用特点，针对AS发生发展过程中巨噬细胞极化稳态失衡这一重要事件，深入研究巨噬细胞表型转化的内在机制。通过研究丹参地上部位三萜成分在整体动物模型、细胞水平、分子水平对巨噬细胞极化稳态的调控，层层验证，阐明丹参地上部位抗AS的物质基础及作用机制，为丹参地上部位的资源利用奠定基础。

Atherosclerosis, the most common cardiovascular disease, is now taking its place as one of the main threats to human health. The balance of macrophage plays a major role in the pathogenesis of atherosclerotic plaques and affects evolution and complications of atherosclerosis. Understanding the molecular mechanisms that orchestrate macrophage polarization should provid a basis for novel treatment strategies to atherosclerosis. Danshen refers to the root and radix of Salvia miltiorrhiza Bunge (Labiatae). The increasing demand of danshen generated large amounts of discarding stems and leaves (the aerial parts of Salvia miltiorrhiza). Meanwhile, our researches have been confirmed the total triterpenoids from the aerial parts of Salvia miltiorrhiza can improving atherosclerosis by regulating the balance of macrophage. In present reseach, we will investigate the molecular mechnisms that regulate the polarization of macrophage by proteomics. Furthermore, we will focus on the discovery of active components in the aerial parts of Salvia miltiorrhiza responsible for the anti-atherosclerosis effect and their probable mechanisms.