重离子治癌在束 TOF-PET全数字化电子学系统关键技术研究

在束TOF-PET作为唯一非侵入性检测的方法，可以解决重离子治瘤时对入射束流定位及剂量的快速、准确影像监测的难题。而与之配套的新型读出电子学系统亟待深入研究。本项目依托在束影像监测技术的发展，拟开展在束TOF-PET全数字化电子学系统的设计和关键技术研究；采用基于开关电容阵列的脉冲数字化技术，并在FPGA中实现时间测量和实时符合判选等数字信号处理算法取代大量传统电路的技术路线；解决在束TOF-PET探测器系统高计数率、高时间分辨率和高精度粒子能量测量的问题，同时将极大地缓解整个系统数据带宽压力，简化软件设计，提高实时性。 .本课题具有方法学上的研究意义，其涉及的技术与方法对跟踪国际前沿和发展高性能医用核电子学、数据获取技术有着十分重要的意义。其研究成果可以促进肿瘤放射治疗关键设备的国产化，它不仅在重离子治癌装置中有着重要的应用需求，而且在其它粒子束放射治疗系统中也有广泛的应用价值和前景。

In-Beam TOF-PET (Time of Flight Positron Emission Tomography) as the only noninvasive method for monitoring of beam position and irradiation dose in heavy ion tumor therapy, it can solve the problem of monitoring the distribution of irradiation dose and the position of heavy ion beam with the imaging methods in the treatment of the heavy ion tumor radiotherapy. However, the electronic system for In-Beam TOF-PET needs to be explored urgently. With the development of beam image monitoring technology, this project is focus on designing an all-digital electronic system used for the In-Beam TOF-PET, and also studying corresponding key technologies. The pulse digitization technology based on the switched capacitor array is adopted. Meanwhile, The FPGA will be used to realize digital signal processing algorithms such as TDC (Time-to-Digital Converter) and coincidence algorithm, etc., which can replace many complicated traditional analog circuits. The electronic system will meet the requirements of In-Beam TOF-PET with high performance, such as high count rate, high time resolution and high precision of particle energy measurement. It also can greatly ease the system data transmission pressure, simplify software design, and improve real-time response. . This project is significant in methodology. The new techniques and methods with the project research are important and meaningful for tracking international frontier and developing new medical nuclear electronics and data acquisition devices. The research results can promote the localization of key devices for tumor radiotherapy, there are application requirements for that not only in heavy ion therapy, but also there are wide application value and prospect in other particle beam radiation therapy system.