Prototype design of readout electronics for In-Beam TOF-PET of Heavy-Ion Cancer Therapy Device
Prototype design of readout electronics for In-Beam TOF-PET of Heavy-Ion Cancer Therapy Device
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重离子癌症治疗装置束内 TOF-PET 读出电子器件原型设计
DOI：
10.1016/j.nima.2020.163492
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Kong J.
中科院分区：
文献类型：
--
作者：
Yan J. W.;Yang H. B.;Ke L. Y.;Niu X. Y.;Chen J. D.;Zhang X. L.;Du C. M.;Su H.;Kong J.
重离子肿瘤治疗仪是中国科学院现代物理研究所研制的一种先进的核医学肿瘤放疗设备。位于束流线上的飞行时间（TOF）正电子发射断层扫描（PET），称为束流内正电子发射断层扫描（in - beam TOF-PET），是HICTD中的关键探测器，用于获取伽马射线的时间、能量和位置信息，实现治疗过程中的实时图像重建。为束流式TOF-PET设计了一种高性能读出电子系统。实现了该系统的关键器件数据采集单元（DAQU）。由DAQU采集和处理束内TOF-PET的信号，包括8条能量链和2条时间链。采用现场可编程门阵列（FPGA）作为板载处理器，实现脉冲区域信息提取算法、基于FPGA的TDC等。精密脉冲星试验表明，DAQU系统对能量分辨率的内在影响优于5.5‰（半最大值全宽度，FWHM），时间分辨率优于255 ps （FWHM）。22na源测试表明，整个系统在511 keV下的能量分辨率为14% FWHM，符合时序分辨率优于1.12 ns。洪水图表明LYSO晶体块探测器具有良好的位置识别能力，在一个LYSO晶体块探测器中，484个晶体都能被清晰地识别出来。
Heavy-Ion Cancer Therapy Device (HICTD) developed by the Institute of Modern Physics of the Chinese Academy of Sciences is an advanced tumor radiotherapy device for nuclear medicine. The time of flight (TOF) positron emission tomography (PET) located on the beam line, called In-Beam TOF-PET, is a key detector in HICTD, which is employed for obtaining time, energy and position information of gamma ray to implement real-time image reconstruction during the treatment. A high performance readout electronics system has been designed for In-Beam TOF-PET. The Data Acquisition Unit (DAQU), a key device of it has been implemented. The signals from the In-Beam TOF-PET are acquired and processed by the DAQU, including 8 energy chains and 2 time chains. A field programmable gate array (FPGA) is adopted as a processor on board for implementing pulse area information extracting algorithm, FPGA-based TDC, and etc. The precision pulsar test indicates that the DAQU system has intrinsic influences on the energy resolution better than 5.5 ‰ (full width at the half-maximum, FWHM) and time resolution of 255 ps (FWHM). The22Na source test indicates that the overall system of the in-beam TOF-PET has an energy resolution of 14% FWHM at 511 keV and coincidence timing resolution better than 1.12 ns. The good position identification ability is indicated by the flood map, all the 484 crystals in one of LYSO crystal block detectors can be clearly distinguished.
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DOI：
10.1016/j.nima.2009.01.086
发表时间：
2009-06
影响因子：
1.4
作者：
H. Alva-Sánchez;A. Martínez-Dávalos;E. Moreno-Barbosa;B. Hernández-Reyes;T. Murrieta;C. Ruiz-Trejo;M. Brandan;M. Rodríguez-Villafuerte
通讯作者：
H. Alva-Sánchez;A. Martínez-Dávalos;E. Moreno-Barbosa;B. Hernández-Reyes;T. Murrieta;C. Ruiz-Trejo;M. Brandan;M. Rodríguez-Villafuerte
重离子肿瘤治疗仪PET信号能量校正算法评估
影响因子：
2.7
作者：
Niu Xiaoyang;Yan Junwei;Wang Xiaohui;Yang Haibo;Ke Lingyun;Chen Jinda;Du Chengming;Zhang Xiuling;Zhao Chengxin;Kong Jie;Su Hong
通讯作者：
Su Hong
DOI：
10.1109/nssmic.1996.591573
发表时间：
1996-11
期刊：
1996 IEEE Nuclear Science Symposium. Conference Record
影响因子：
--
作者：
J. Pawelke;Wolfgang Enghardt;T. Haberer;B. Hasch;Rainer Hinz;Michael Krämer;K. Lauckner;M. Sobiella
通讯作者：
J. Pawelke;Wolfgang Enghardt;T. Haberer;B. Hasch;Rainer Hinz;Michael Krämer;K. Lauckner;M. Sobiella
影响因子：
3.5
作者：
M. Lazzeroni;Anders Brahme
通讯作者：
M. Lazzeroni;Anders Brahme
影响因子：
1.8
作者：
Pawelke, J;Enghardt, W;Sobiella, M
通讯作者：
Sobiella, M