氧鎓离子可作为关键中间体用于复杂天然产物及药物分子的合成。虽然具有较高的反应活性，但却很难与手性Lewis酸或者氢键供体结合，使得其手性合成存在极大挑战，目前成功的例子主要集中在硅醚或硼酯对六元氧鎓离子的亲核加成。因此，设计新型五元氧鎓离子，实现其与多种亲核试剂的多种类型反应具有重要的意义。基于前期对不对称新反应设计的研究，结合预实验的结果，本项目拟以五元异苯并呋喃氧鎓离子前体为起始物，发散地发展多种新型的亲核加成、骨架重排、切换反应、串联反应等，快速构建多种骨架多样、结构复杂、三维立体多样的优势骨架化合物库，用于表型筛选与评价，发展具有药用前景的苗头化合物或先导化合物。

Oxocarbenium ions have been utilized as key intermediates in many transformations for the synthesis of bioactive natural products and pharmaceuticals. Their high reactivities and lack of activation sites with chiral Lewis acids or hydrogen bond donors impede the development of asymmetric reactions. The successful examples are limited to the nucleophilic addition of silyl ketenes or boronates to six-membered oxocarbenium ions. The development five-membered ring systems to realize various types of reactions with different nucleophiles is of great significance. Based on our previous study and the results of preliminary experiments, we'll intend to dedivergently develop various types of reactions like nucleophilic addition, rearrangement reaction, switchable reaction and tandem reaction of five-membered oxocarbenium ions with various nucleophiles for the rapid construction of structurally complex and diverse compound libraries. We’ll use these new compounds in phenotypic screening and evaluation for the development of potent leading compounds.