基于农业可持续发展的需要，开发高效、低毒、低残留的绿色植物源农药就变得非常紧迫和重要。本课题以天然产物松香为主要原料，通过活性亚结构拼接原理制备系列新型松香基噻吩杂环杀虫剂，并进行光活化杀虫活性研究；在活性筛选的基础上，结合症状学、组织病理学、分子毒理学和电子自旋共振等手段对其光诱导氧化作用机理进行分析，着重考察松香的独特分子结构增效杀虫活性的光诱导氧化作用方式；通过密度泛函理论，研究药剂分子的手性中心、空间效应、电荷分布和能量变化等调控靶标位点的光动力学反应；建立松香基噻吩杂环分子对应于光活化杀虫活性的定量关系模型，从分子、电子的结构水平进一步揭示药剂和受体的结合方式及作用机制。通过上述研究，可为新型高效松香基光活化杀虫剂的设计合成提供理论指导，并为松香在生物农药领域的高值化利用奠定基础。

Based on requirements of agricultural sustainable development, the development of green botanical pesticide of high efficiency, low toxicity and residue becomes very urgent and important. In this proposal, natural product rosin is chosen as the main raw materials, and a series of rosin-based thiophene heterocyclic molecules with different link structures are designed and synthesized by active substructure combination method. Meanwhile, the photoactivated insecticidal activity of target compounds is evaluated. On the basis of the screening of insecticidal activity, the mechanism of photoinduced oxidation of rosin-based thiophene heterocyclic compounds combined with symptomatology, histopathology, molecular toxicology and electron spin resonance method is systematically studied. How the unique molecular structure of rosin to influence the synergism of photoactivated insecticidal activity is especially focused. Through the density functional theory, the regulation of photodynamic reaction of target site by the chiral center, space effect, charge distribution and energy changes induced by light activation of rosin-based thiophene heterocyclic compounds on the insecticidal activity is investigated. In addition, the quantitative relationship model of the rosin-based thiophene heterocyclic compounds corresponding to the photoactivated insecticidal activity is built. The binding mode and insecticidal action mechanism of rosin-based molecules with receptors would be revealed at the level of molecular and electronic structure. These theories obtained in this study would provide guidance in the further design of rosin-based botanical insecticides, thus achieving the higher value-added applications of rosin in bio-pesticide field.