课题组前期发现，随着妊娠的进展，孕妇睡眠呼吸障碍（Sleep-Disordered Breathing, SDB）的发生率逐步上升，症状逐渐加重，使机体处于氧化应激和炎症反应状态。基于此发现，本项目分别于孕早、中、晚期纵向随访SDB的发病及病情分级评分，前瞻性评估其与妊娠合并症、分娩结局和婴幼儿神经行为发育之间的关联，评价可能的剂量-效应关系，寻找SDB暴露危险窗口。以氧化应激、炎症反应和心血管、胎盘血流动力学为生物效应指标，探讨妊娠SDB对母婴围产健康影响的生物学机制，构建妊娠SDB-生物效应-围产结局之间的数学模型；以婴幼儿神经行为发育水平为远期健康结局，阐述妊娠SDB在胎儿下丘脑-垂体-肾上腺轴发育宫内编程和表观遗传修饰中的作用及远期效应。本研究关注到妊娠这一孕育生命的特定阶段，比较系统阐述妊娠SDB对母婴健康的影响及潜在生物学机制，对于丰富孕期保健理论知识和促进优生优育意义重要。

Our previous research indicated that the prevalence of sleep-disordered breathing (SDB) increases as pregnancy progresses and severe symptoms may occur gradually which result in both a state of oxidative stress and inflammatory responses. Based on these findings, a prospective cohort longitudinal study is specifically designed to observe the prevalence and severity of SDB at the first, second and third trimester of pregnancy. The present study also attempts to examine the associations between SDB and several outcome measurements including pregnancy complications, birth outcomes and infant neurobehavioral development status. The following research questions will be specifically concerned: whether or not the above associations are dose-dependent, and whether or not there is a susceptible period to SDB exposure with different research outcomes. Furthermore, the biological mechanisms underlying these associations would be comprehensively explored: ① How exposure to SDB during pregnancy affects the state of oxidative stress, inflammatory reaction and hemodynamic changes; and ② potential epigenetic modifications of cortisol-related signaling pathway and the methylation status of key genes on this pathway. In summary, this study systematically examines the impact of SDB exposure during pregnancy on maternal and child health which could be potentially explained by biological mechanisms. All of the above evidence may be significant to prenatal care which can be used in clinical practices in order to enhance aristogenesis and stirpiculture.