纳米递药系统在体内应用时，递药系统与体液蛋白的相互作用是最早发生的，并持续影响整个转运过程，而目前对该影响过程尚缺少系统深入的了解。本课题拟以纳米递药系统在体液中形成的蛋白冠状物及其在体内的转运过程为研究对象，深入研究递药系统进入体内后与组织蛋白相互作用形成蛋白冠状物的组成及形成规律；分析冠状物对递药系统的材料结构和生物学活性的影响；阐明形成冠状物后，递药系统与机体滤过系统、免疫系统、组织微环境以及靶细胞相互作用过程和作用机制；从而评估冠状物形成对递药系统体内转运的影响，在此基础之上发展基于冠状物形成和影响规律的纳米递药系统，并用于治疗两种严重危害人类生命健康的纤维化疾病。该课题有助于加深对纳米递药系统与机体生命系统的相互作用过程的理解，完善纳米递药系统研发的理论基础，在此基础之上所提出的有针对性的递药系统设计制备方案，则可望有效推进递药系统的技术发展及其在纤维化疾病中的应用。

When applied in vivo, nano drug delivery system are in a constant interactions with the physiological system. The interactions between the proteins in body fluids and the drug delivery system happen at the very first and will influence all though the transfer. However, few systemic studies were focused on the influence process. In the present proposed study, we will analyze the component of the protein corona formed on the nano drug delivery system. After that, we will study the influences of the corona on the material properties and bioactivities of the nano drug delivery system, and further the interactions between the drug delivery system and the filtration system, the immune system, the tissue microenvironments and the target cells mediated by the corona. Based on the proposed studies, we will develop novel nano drug delivery system according to the rule of corona formation and influence. And the drug delivery system will be used to treat two fibrosis diseases that seriously endanger human life. This object can deepen our understanding of the interaction between drug delivery system and the physiological system, and improve the theoretical basis for developing nano drug delivery system. The design and preparation scheme of specific nano drug delivery system based on the theoretical basis will facilitate the development of new drug delivery technics and its clinical application in fibrotic diseases.