长寿浆细胞在防御病原体方面起着重要的作用。因此，了解长寿浆细胞的存活和生物学功能对于以下两个方面是非常重要的，设计更好的疫苗以产生高效的免疫应答以及针对相关的免疫学疾病如红斑狼疮疾病等筛选出更好的小分子化学药物。最近报道Ufm1类泛素化修饰系统在分泌型细胞中起着重要作用, 但是具体的机制不清楚。浆细胞是B细胞的终极分化细胞也是抗体分泌细胞。Ufbp1和Ufl1复合体是Ufm1类泛素化修饰系统的E3连接酶。我们发表的工作表明Ufbp1在B细胞发育到浆细胞的过程中起着不可缺失的作用。我们的前期工作也显示Ufbp1和Ufl1在长寿浆细胞的存活和生物学功能中起着十分重要的作用。在本课题中，我们将进一步阐明Ufbp1和Ufl1在长寿浆细胞的存活和生物学功能中的作用和分子机制，为开发新型疗法和候选基因提供新的理论基础，并筛选针对红斑狼疮疾病和其他浆细胞疾病的潜在药物。

Long lived plasma cells play an essential role in protection against pathogens. Therefore, understanding the survival and function of long lived plasma cells are important in designing better vaccines to generate effective immune response and screening better small molecular chemical drugs against related immune diseases like systemic lupus erythematosus (SLE). Recently, it has been reported that the ufm1 conjugation system, ubiquitin-like modification system, is suggested to play an indispensable role in secretory cells. But the underlying mechanism is unknown. Plasma cells are antibody secreting cells and terminal differentiation of B cells. Ufl1 and Ufbp1 are in one complex as E3 ligase in ufmylation. We established the conditional knockout mouse models of Ufl1 or Ufbp1 in B cells. Our published work demonstrated the novel role of Ufbp1 during B cell differentiation to plasma cell. Furthermore, our preliminary study shows that Ufbp1 and Ufl1 play a critical role in survival and function of long lived plasma cells. In this study, we will further elucidate the survival, function and mechanism of Ufl1/Ufbp1 mediated regulation of long live plasma cells. Our study will provide insight on new theoretical basis for development of novel therapies and candidate genes and screen the potential drugs against SLE as well as other plasma cell diseases.