无衬底纹身电极因其超薄结构在生物电检测领域具有独特优势，兼具与皮肤贴合程度高、抗运动伪迹、透气等优点，是未来穿戴式心电监护仪最具潜力的心电电极。然而目前无衬底纹身电极面临粘附性能不足的技术瓶颈。申请人创新性地提出基于PEDOT:PSS无衬底纹身心电电极的基础研究，结合最小能量原理和PEDOT:PSS凝胶与干电极转化的新特性，围绕电极在皮肤表面受控凝胶化再干燥的体系能量调控机制、完全共形贴合和长效粘附的机理、超薄电极制备及转印工艺等重要科学及核心技术问题开展基础研究。本项目的创新性在于构建PEDOT:PSS通过分子链调整产生无应力拉伸与皮肤完全共形贴合、建立强分子间氢键增强电极-皮肤界面粘附强度的机制，为实现与皮肤完全共形贴合且长效粘附的无衬底纹身心电电极提供理论和技术支撑。项目的开展将助力提升我国在穿戴式心电监护的研究水平，对于解决庞大心血管病患者群体的心电监护问题意义重大。

With the ultra-thin structure, substrate-free tattoo electrode has unique advantages in the field of bioelectrical detection, as it has the advantages of high skin fit, anti-motion artifact, air permeability, etc. It is the most promising ECG electrode for wearable ECG monitoring in the future. However, at present, substrate-free tattoo electrode faces the technical bottleneck of insufficient adhesion performance. The applicant proposed an innovative and basic study of PEDOT:PSS based substrate-free tattoo electrocardiography electrode. Combining the principle of minimum energy and the new transformation feature of PEDOT:PSS gel and dry electrode, this project will study the important scientific and core technologies: the system energy regulation mechanism by controlled transformation between gel gelation and re-drying on the skin surface; the mechanism of fully conformal contact and adhesion; the preparation of ultra-thin electrodes and the transfer printing process. The innovation of this project lies in producing stress-free stretching and fully conformal contact by molecular chain adjustment; and enhancing the adhesion strength between electrode and skin interface by establishment of strong intermolecular hydrogen bonding. This project will provide theoretical and technical support for the realization of fully conformal contact with skin and long-term adhesion. The study will help to improve the research level of wearable electrocardiographic monitoring in China, which is of great significance to solve the monitoring of a large number of cardiovascular patients.